Search: onr:"swepub:oai:lup.lub.lu.se:35bacba6-990b-4f27-84ef-343fafd5a60e" >
Excitation and cont...
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Arlock, PerKarolinska Institute,Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
(author)
Excitation and contraction of cardiac muscle and coronary arteries of brain-dead pigs
- Article/chapterEnglish2023
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Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:35bacba6-990b-4f27-84ef-343fafd5a60e
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https://lup.lub.lu.se/record/35bacba6-990b-4f27-84ef-343fafd5a60eURI
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https://doi.org/10.1096/fba.2022-00104DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:236816513URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Excitability and contraction of cardiac muscle from brain-dead donors critically influence the success of heart transplantation. Membrane physiology, Ca2+-handling, and force production of cardiac muscle and the contractile properties of coronary arteries were studied in hearts of brain-dead pigs. Cardiac muscle and vascular function after 12 h brain death (decapitation between C2 and C3) were compared with properties of fresh tissue. In both isolated cardiomyocytes (whole-cell patch clamp) and trabecular muscle (conventional microelectrodes), action potential duration was shorter in brain dead, compared to controls. Cellular shortening and Ca2+ transients were attenuated in the brain dead, and linked to lower mRNA expression of L-type calcium channels and a slightly lower ICa,L, current, as well as to a lower expression of phospholamban. The current–voltage relationship and the current above the equilibrium potential of the inward K+ (IK1) channel were altered in the brain-dead group, associated with lower mRNA expression of the Kir2.2 channel. Delayed K+ currents were detected (IKr, IKs) and were not different between groups. The transient outward K+ current (Ito) was not observed in the pig heart. Coronary arteries exhibited increased contractility and sensitivity to the thromboxane analogue (U46619), and unaltered endothelial relaxation. In conclusion, brain death involves changes in cardiac cellular excitation which might lower contractility after transplantation. Changes in the inward rectifier K+ channel can be associated with an increased risk for arrhythmia. Increased reactivity of coronary arteries may lead to increased risk of vascular spasm, although endothelial relaxant function was well preserved.
Subject headings and genre
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Li, MeiKarolinska Institute,Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)me2712li
(author)
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Davis, BenjaminKarolinska Institute
(author)
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Lövdahl, CeciliaKarolinska Institutet,Karolinska Institute
(author)
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Liao, QiumingLund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)thor-qli
(author)
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Sjöberg, TrygveLund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Hjärt-lungsjukdom - information, stöd och bemötande,Heart and Lung transplantation,Lund University Research Groups,Cardiopulmonary disease - information, support and reception(Swepub:lu)thor-tsj
(author)
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Rahman, AwahanKarolinska Institute
(author)
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Wohlfart, BjörnLund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)klfy-bwo
(author)
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Steen, StigLund University,Lunds universitet,Hjärt- och lungtransplantation,Forskargrupper vid Lunds universitet,Heart and Lung transplantation,Lund University Research Groups(Swepub:lu)thor-sst
(author)
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Arner, AndersKarolinska Institute,Lund University,Lunds universitet,Thoraxkirurgi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Thoracic Surgery,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)an8151ar
(author)
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ThoraxkirurgiSektion II
(creator_code:org_t)
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In:FASEB BioAdvances: Wiley5:2, s. 71-842573-9832
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Arlock, Per
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Li, Mei
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Davis, Benjamin
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Lövdahl, Cecilia
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Liao, Qiuming
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Sjöberg, Trygve
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Rahman, Awahan
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Wohlfart, Björn
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Steen, Stig
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Arner, Anders
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Karolinska Institutet