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Complex Involvement...
Complex Involvement of Interleukin-26 in Bacterial Lung Infection
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- Che, Karlhans F. (author)
- Karolinska Institutet
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- Paulsson, Magnus (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Luftvägar, patogener, immunförsvar,Clinical Microbiology, Malmö,Lund University Research Groups,Airways, pathogens, innate immunity,Skåne University Hospital
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- Piersiala, Krzysztof (author)
- Karolinska Institutet
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- Sax, Jakob (author)
- Karolinska Institutet
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- Mboob, Ibrahim (author)
- Karolinska Institutet
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- Rahman, Mizanur (author)
- Karolinska Institutet
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- Rekha, Rokeya S. (author)
- Karolinska Institutet
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- Säfholm, Jesper (author)
- Karolinska Institutet
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- Adner, Mikael (author)
- Karolinska Institutet
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- Bergman, Peter (author)
- Karolinska Institutet
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- Cardell, Lars-Olaf (author)
- Karolinska Institutet,Karolinska University Hospital
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- Riesbeck, Kristian (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Lindén, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-10-28
- 2021
- English.
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In: Frontiers in Immunology. - : Frontiers Media SA. - 1664-3224. ; 12, s. 1-18
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Abstract
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- Pneumonia is a global cause of mortality, and this provides a strong incentive to improve the mechanistic understanding of innate immune responses in the lungs. Here, we characterized the involvement of the cytokine interleukin (IL)-26 in bacterial lung infection. We observed markedly increased concentrations of IL-26 in lower airway samples from patients with bacterial pneumonia and these correlated with blood neutrophil concentrations. Moreover, pathogen-associated molecular patterns (PAMPs) from both Gram-negative and -positive bacteria increased extracellular IL-26 concentrations in conditioned media from human models of alveolar epithelial cells, macrophages, and neutrophils in vitro. Stimulation with IL-26 inhibited the inherent release of neutrophil elastase and myeloperoxidase in unexposed neutrophils. This stimulation also inhibited the expression of activity makers in neutrophils exposed to Klebsiella pneumoniae. In addition, priming of human lung tissue ex vivo with exogenous IL-26 potentiated the endotoxin-induced increase in mRNA for other cytokines involved in the innate immune response, including the master Th17-regulator IL-23 and the archetype inhibitory cytokine IL-10. Finally, neutralization of endogenous IL-26 clearly increased the growth of Klebsiella pneumoniae in the macrophage culture. These findings suggest that IL-26 is involved in bacterial lung infection in a complex manner, by modulating critical aspects of innate immune responses locally and systemically in a seemingly purposeful manner and by contributing to the killing of bacteria in a way that resembles an antimicrobial peptide. Thus, IL-26 displays both diagnostic and therapeutic potential in pneumonia and deserves to be further evaluated in these respects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Che, Karlhans F.
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Paulsson, Magnus
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Piersiala, Krzys ...
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Sax, Jakob
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Mboob, Ibrahim
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Rahman, Mizanur
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show more...
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Rekha, Rokeya S.
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Säfholm, Jesper
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Adner, Mikael
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Bergman, Peter
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Cardell, Lars-Ol ...
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Riesbeck, Kristi ...
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Lindén, Anders
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Frontiers in Imm ...
- By the university
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Lund University
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Karolinska Institutet