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Development of type...
Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
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Niklasson, Bo (author)
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Heller, Knud E (author)
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Schønecker, Bryan (author)
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Bildsøe, Mogens (author)
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Daniels, Terri (author)
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Hampe, Christiane S (author)
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Widlund, Per (author)
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Simonson, William T (author)
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Schaefer, Jonathan B (author)
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Rutledge, Elizabeth (author)
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Bekris, Lynn (author)
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Lindberg, A Michael (author)
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Johansson, Susanne (author)
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Ortqvist, Eva (author)
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Persson, Bengt (author)
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- Lernmark, Åke (author)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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(creator_code:org_t)
- Hindawi Limited, 2003
- 2003
- English.
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In: International journal of experimental diabesity research. - : Hindawi Limited. ; 4:1, s. 35-44
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Abstract
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- Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Niklasson, Bo
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Heller, Knud E
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Schønecker, Brya ...
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Bildsøe, Mogens
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Daniels, Terri
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Hampe, Christian ...
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show more...
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Widlund, Per
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Simonson, Willia ...
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Schaefer, Jonath ...
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Rutledge, Elizab ...
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Bekris, Lynn
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Lindberg, A Mich ...
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Johansson, Susan ...
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Ortqvist, Eva
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Persson, Bengt
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Lernmark, Åke
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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Experimental Dia ...
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Lund University