Search: onr:"swepub:oai:lup.lub.lu.se:36c49321-1314-492d-9366-f3647b411806" >
Development of type...
Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.
- Article/chapterEnglish2003
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:36c49321-1314-492d-9366-f3647b411806
-
https://lup.lub.lu.se/record/1127426URI
-
https://doi.org/10.1080/15438600303733DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Heller, Knud E
(author)
-
Schønecker, Bryan
(author)
-
Bildsøe, Mogens
(author)
-
Daniels, Terri
(author)
-
Hampe, Christiane S
(author)
-
Widlund, Per
(author)
-
Simonson, William T
(author)
-
Schaefer, Jonathan B
(author)
-
Rutledge, Elizabeth
(author)
-
Bekris, Lynn
(author)
-
Lindberg, A Michael
(author)
-
Johansson, Susanne
(author)
-
Ortqvist, Eva
(author)
-
Persson, Bengt
(author)
-
Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale
(author)
-
Celiaki och diabetesForskargrupper vid Lunds universitet
(creator_code:org_t)
Related titles
-
In:International journal of experimental diabesity research: Hindawi Limited4:1, s. 35-44
-
In:Experimental Diabesity Research: Hindawi Limited4:1, s. 35-441543-86001543-8619
Internet link
Find in a library
To the university's database
- By the author/editor
-
Niklasson, Bo
-
Heller, Knud E
-
Schønecker, Brya ...
-
Bildsøe, Mogens
-
Daniels, Terri
-
Hampe, Christian ...
-
show more...
-
Widlund, Per
-
Simonson, Willia ...
-
Schaefer, Jonath ...
-
Rutledge, Elizab ...
-
Bekris, Lynn
-
Lindberg, A Mich ...
-
Johansson, Susan ...
-
Ortqvist, Eva
-
Persson, Bengt
-
Lernmark, Åke
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
- International jo ...
-
Experimental Dia ...
- By the university
-
Lund University