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Search: onr:"swepub:oai:lup.lub.lu.se:36c49321-1314-492d-9366-f3647b411806" > Development of type...

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  • Niklasson, Bo (author)

Development of type 1 diabetes in wild bank voles associated with islet autoantibodies and the novel ljungan virus.

  • Article/chapterEnglish2003

Publisher, publication year, extent ...

  • Hindawi Limited,2003

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:36c49321-1314-492d-9366-f3647b411806
  • https://lup.lub.lu.se/record/1127426URI
  • https://doi.org/10.1080/15438600303733DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Wild bank voles (Clethrionomys glareolus) may develop diabetes in laboratory captivity. The aim of this study was to test whether bank voles develop type 1 diabetes in association with Ljungan virus. Two groups of bank voles were analyzed for diabetes, pancreas histology, autoantibodies to glutamic acid decarboxylase (GAD65), IA-2, and insulin by standardized radioligand-binding assays as well as antibodies to in vitro transcribed and translated Ljungan virus antigens. Group A represented 101 trapped bank voles, which were screened for diabetes when euthanized within 24 hours of capture. Group B represented 67 bank voles, which were trapped and kept in the laboratory for 1 month before being euthanized. Group A bank voles did not have diabetes. Bank voles in group B (22/67; 33%) developed diabetes due to specific lysis of pancreatic islet beta cells. Compared to nondiabetic group B bank voles, diabetic animals had increased levels of GAD65 (P < .0001), IA-2 (P < .0001), and insulin (P

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Heller, Knud E (author)
  • Schønecker, Bryan (author)
  • Bildsøe, Mogens (author)
  • Daniels, Terri (author)
  • Hampe, Christiane S (author)
  • Widlund, Per (author)
  • Simonson, William T (author)
  • Schaefer, Jonathan B (author)
  • Rutledge, Elizabeth (author)
  • Bekris, Lynn (author)
  • Lindberg, A Michael (author)
  • Johansson, Susanne (author)
  • Ortqvist, Eva (author)
  • Persson, Bengt (author)
  • Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale (author)
  • Celiaki och diabetesForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:International journal of experimental diabesity research: Hindawi Limited4:1, s. 35-44
  • In:Experimental Diabesity Research: Hindawi Limited4:1, s. 35-441543-86001543-8619

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