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Search: onr:"swepub:oai:lup.lub.lu.se:36ee103d-894a-40f8-a506-a118f265ba04" > A retrospective stu...

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  • Karimi, MasoudKarolinska University Hospital (author)

A retrospective study of extracolonic, non-endometrial cancer in Swedish Lynch syndrome families 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 11 Medical and Health Sciences 1117 Public Health and Health Services

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-10-23
  • Springer Science and Business Media LLC,2018

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  • LIBRIS-ID:oai:lup.lub.lu.se:36ee103d-894a-40f8-a506-a118f265ba04
  • https://lup.lub.lu.se/record/36ee103d-894a-40f8-a506-a118f265ba04URI
  • https://doi.org/10.1186/s13053-018-0098-9DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background: Lynch Syndrome is an autosomal dominant cancer syndrome caused by pathogenic germ-line variants in one of the DNA-mismatch-repair (MMR) genes MLH1, MSH2, MSH6 or PMS2. Carriers are predisposed to colorectal and endometrial cancer, but also other cancer types. The purpose of this retrospective study was to characterize the tumour spectrum of the Swedish Lynch syndrome families. Methods: Data were obtained from genetically verified 235 Lynch families from five of the six health care regions in Sweden. The material was stratified for gender, primary cancer, age and mutated gene and the relative proportions of specific cancer types were compared to those in the general population. Results: A total of 1053 family members had 1493 cancer diagnoses of which 1011 were colorectal or endometrial cancer. Individuals with pathogenic variants in MLH1 and MSH2 comprised 78% of the cohort. Among the 482 non-colorectal/non-endometrial cancer diagnoses, MSH2 carriers demonstrated a significantly increased proportion of urinary tract, gastric, small bowel, ovarian and non-melanoma skin cancer compared to the normal population. MLH1 carriers had an elevated proportion of gastrointestinal cancers (gastric, small bowel, pancreas), while MSH6 carriers had more ovarian cancer than expected. Gastric cancer was predominantly noted in older generations. Conclusion: Lynch syndrome confers an increased risk for multiple cancers other than colorectal and endometrial cancer. The proportions of other cancers vary between different MMR genes, with highest frequency in MSH2-carriers. Gender and age also affect the tumour spectrum, demonstrating the importance of additional environmental and constitutional parameters in determining the predisposition for different cancer types.

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  • Von Salomé, JennyKarolinska Institute,Karolinska University Hospital (author)
  • Aravidis, ChristosUppsala University Hospital (author)
  • Silander, GustavNorrland University Hospital (author)
  • Askmalm, Marie StenmarkLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Linköping University Hospital(Swepub:lu)med-ms43 (author)
  • Henriksson, IsabelleLund University (author)
  • Gebre-Medhin, SamuelLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)mphy-sgm (author)
  • Frödin, Jan ErikKarolinska University Hospital (author)
  • Björck, ErikKarolinska Institute,Karolinska University Hospital (author)
  • Lagerstedt-Robinson, KristinaKarolinska Institute,Karolinska University Hospital (author)
  • Lindblom, AnnikaKarolinska Institute,Karolinska University Hospital (author)
  • Tham, EmmaKarolinska Institute,Karolinska University Hospital (author)
  • Karolinska InstituteKarolinska University Hospital (creator_code:org_t)

Related titles

  • In:Hereditary Cancer in Clinical Practice: Springer Science and Business Media LLC16:11731-23021897-4287

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