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Diagnostic efficacy...
Diagnostic efficacy of MnDPDP in MR imaging of the liver. A phase III multicentre study
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- Wang, C (author)
- Uppsala universitet,Enheten för radiologi
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- Ahlstrom, H (author)
- Uppsala universitet,Enheten för radiologi
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Ekholm, S (author)
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Fagertun, H (author)
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Hellstrom, M (author)
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- Hemmingsson, A (author)
- Uppsala universitet,Enheten för radiologi
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- Holtås, Stig (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Isberg, B (author)
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Jonnson, E (author)
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- Lonnemark-Magnusson, M (author)
- Uppsala universitet,Enheten för radiologi
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McGill, S (author)
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Wallengren, N O (author)
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Westman, L (author)
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(creator_code:org_t)
- 1997
- 1997
- English.
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In: Acta Radiologica. - 1600-0455 .- 0284-1851. ; 38:4, s. 643-649
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Abstract
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- PURPOSE: To assess the diagnostic efficacy, safety and tolerability of mangafodipir trisodium (MnDPDP, Teslascan) in MR imaging of the liver. MATERIAL AND METHODS: Eighty-two patients from 4 centres underwent MR imaging with pre-contrast sequences including T1-weighted SE and GRE, and T2-weighted turbo SE sequences. MnDPDP at a dose of 5 mumol/kg b.w. was administered by slow i.v. infusion, and 20-60 min after infusion the T1-weighted SE and GRE sequences were repeated. Diagnostic efficacy was evaluated by counting the number of lesions and by evaluating whether more information for lesion characterisation was available in post-contrast images. Safety and tolerability were assessed by recording adverse events and infusion-related discomfort. RESULTS: Significantly more lesions were found in MnDPDP-enhanced T1-weighted SE and GRE images than in unenhanced images of the same sequences. More lesions were also found in these images compared with T2-weighted images at a level of marginal significance. More information was obtained from MnDPDP-enhanced images in 40 cases. Mild to moderate adverse events were experienced by 17% of the patients. CONCLUSION: MnDPDP-enhanced images can improve lesion detection in the liver and are helpful for lesion characterisation. To obtain optimal diagnostic information of liver lesions T2-weighted images are also valuable. MnDPDP is a safe contrast agent for MR imaging of liver lesions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Wang, C
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Ahlstrom, H
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Ekholm, S
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Fagertun, H
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Hellstrom, M
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Hemmingsson, A
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show more...
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Holtås, Stig
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Isberg, B
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Jonnson, E
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Lonnemark-Magnus ...
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McGill, S
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Wallengren, N O
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Westman, L
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Acta Radiologica
- By the university
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Lund University
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Uppsala University