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From biochemical ma...
From biochemical markers to molecular endotypes of osteoarthritis : a review on validated biomarkers
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- Hannani, Monica T. (author)
- University of Copenhagen,Nordic Bioscience AS
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- Thudium, Christian S. (author)
- Nordic Bioscience AS
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- Karsdal, Morten A. (author)
- Nordic Bioscience AS
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Ladel, Christoph (author)
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- Mobasheri, Ali (author)
- University of Oulu,First Affiliated Hospital of Sun Yat-sen University,University of Liège
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- Uebelhoer, Melanie (author)
- Artialis SA
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- Larkin, Jonathan (author)
- University of Oulu
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- Bacardit, Jaume (author)
- University of Newcastle upon Tyne
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- Struglics, André (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund OsteoArthritis Division - Nedbrytning av ledbrosk: en biologisk process som leder till artros,Forskargrupper vid Lunds universitet,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund OsteoArthritis Division - Molecular marker research group,Lund University Research Groups
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- Bay-Jensen, Anne Christine (author)
- Nordic Bioscience AS
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(creator_code:org_t)
- 2024
- 2024
- English 16 s.
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In: Expert Review of Molecular Diagnostics. - 1473-7159. ; 24:1-2, s. 23-38
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Abstract
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- Introduction: Osteoarthritis (OA) affects over 500 million people worldwide. OA patients are symptomatically treated, and current therapies exhibit marginal efficacy and frequently carry safety-risks associated with chronic use. No disease-modifying therapies have been approved to date leaving surgical joint replacement as a last resort. To enable effective patient care and successful drug development there is an urgent need to uncover the pathobiological drivers of OA and how these translate into disease endotypes. Endotypes provide a more precise and mechanistic definition of disease subgroups than observable phenotypes, and a panel of tissue- and pathology-specific biochemical markers may uncover treatable endotypes of OA. Areas covered: We have searched PubMed for full-text articles written in English to provide an in-depth narrative review of a panel of validated biochemical markers utilized for endotyping of OA and their association to key OA pathologies. Expert opinion: As utilized in IMI-APPROACH and validated in OAI-FNIH, a panel of biochemical markers may uncover disease subgroups and facilitate the enrichment of treatable molecular endotypes for recruitment in therapeutic clinical trials. Understanding the link between biochemical markers and patient-reported outcomes and treatable endotypes that may respond to given therapies will pave the way for new drug development in OA.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Biochemical marker
- biomarker
- bone remodeling
- cartilage
- endotype
- endotyping
- osteoarthritis
- patient stratification
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- ref (subject category)
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Hannani, Monica ...
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Thudium, Christi ...
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Karsdal, Morten ...
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Ladel, Christoph
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Mobasheri, Ali
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Uebelhoer, Melan ...
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show more...
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Larkin, Jonathan
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Bacardit, Jaume
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Struglics, André
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Bay-Jensen, Anne ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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Expert Review of ...
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Lund University