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  • Romieu, IsabelleInternational Agency for Research on Cancer, World Health Organization (author)

Fiber intake modulates the association of alcohol intake with breast cancer

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2016-11-21
  • Wiley,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:38732062-a382-403f-8b68-712db346d7bf
  • https://lup.lub.lu.se/record/38732062-a382-403f-8b68-712db346d7bfURI
  • https://doi.org/10.1002/ijc.30415DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-129409URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:134926491URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization (author)
  • Chajès, VeroniqueInternational Agency for Research on Cancer, World Health Organization (author)
  • de Batlle, JordiInternational Agency for Research on Cancer, World Health Organization (author)
  • Biessy, CarineInternational Agency for Research on Cancer, World Health Organization (author)
  • Scoccianti, ChiaraInternational Agency for Research on Cancer, World Health Organization (author)
  • Dossus, LaureInstitut Gustave Roussy (author)
  • Christine Boutron, MarieInstitut Gustave Roussy (author)
  • Bastide, NadiaInstitut Gustave Roussy (author)
  • Overvad, KimAarhus University (author)
  • Olsen, AnjaDanish Cancer Society (author)
  • Tjønneland, AnneDanish Cancer Society (author)
  • Kaaks, RudolfGerman Cancer Research Centre (author)
  • Boeing, HeinerGerman Institute of Human Nutrition (author)
  • Trichopoulou, AntoniaNational and Kapodistrian University of Athens (author)
  • Lagiou, PagonaAcademy of Athens (author)
  • Trichopoulos, DimitriosHellenic Health Foundation, Athens (author)
  • Palli, DomenicoCancer Research and Prevention Institute (ISPO) (author)
  • Sieri, SabinaIstituto Nazionale dei Tumori (author)
  • Tumino, RosarioCivic and M.P Arezzo Hospital (author)
  • Vineis, PaoloHuman Genetics Foundation (HuGeF) (author)
  • Panico, SalvatoreUniversity of Naples Federico II (author)
  • Bueno-de-Mesquita, H. BasUniversity of Malaya (author)
  • Gils, Carla H.University Medical Center Utrecht (author)
  • Peeters, Petra H.Imperial College London (author)
  • Lund, EilivUiT The Arctic University of Norway, Tromsø (author)
  • Skeie, GuriUiT The Arctic University of Norway, Tromsø (author)
  • Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute (author)
  • Ramón Quirós, J.Public Health Directorate (author)
  • Chirlaque, María DoloresMurcia Regional Health Authority (author)
  • Ardanaz, EvaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Health Research Institute of Navarra (IDISNA)(Swepub:lu)extLU-05 (author)
  • Sánchez, María JoséAndalusian School Of Public Health (EASP) (author)
  • Duell, Eric J.Catalan Institute of Oncology (author)
  • Amiano Etxezarreta, PilarCIBER Epidemiology and Public Health (CIBERESP) (author)
  • Borgquist, SigneLund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund,Breast cancer prevention & intervention,Lund University Research Groups(Swepub:lu)ront-sbo (author)
  • Hallmans, GöranUmeå universitet,Umeå University,Näringsforskning(Swepub:umu)goha0001 (author)
  • Johansson, IngegerdUmeå universitet,Umeå University,Institutionen för odontologi(Swepub:umu)injo0003 (author)
  • Maria Nilsson, LenaUmeå universitet,Umeå University,Näringsforskning(Swepub:umu)leni0002 (author)
  • Khaw, Kay TeeUniversity of Cambridge (author)
  • Wareham, NickUniversity of Cambridge (author)
  • Key, Timothy J.University of Oxford (author)
  • Travis, Ruth C.University of Oxford (author)
  • Murphy, NeilImperial College London (author)
  • Wark, Petra A.Imperial College London (author)
  • Riboli, ElioImperial College London (author)
  • International Agency for Research on Cancer, World Health OrganizationInstitut Gustave Roussy (creator_code:org_t)

Related titles

  • In:International Journal of Cancer: Wiley140:2, s. 316-3210020-71361097-0215

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