Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA : Methodological limitations and convergent results

Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.

Vogel, Jacob W.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,University of Pennsylvania(Swepub:lu)ja8870vo (author)
Sydnor, Valerie J.University of Pennsylvania (author)
Pines, AdamUniversity of Pennsylvania,Stanford University (author)
Wellman, NickUniversity of Pennsylvania (author)
Basbaum, AllanUniversity of California, San Francisco (author)
Eickhoff, Claudia R.Jülich Research Centre (author)
Eickhoff, Simon B.Jülich Research Centre (author)
Edwards, Robert R.Harvard Medical School (author)
Larsen, BartUniversity of Pennsylvania (author)
McKinstry-Wu, AndrewUniversity of Pennsylvania (author)
Scott, J. CobbVeterans Health Administration,University of Pennsylvania (author)
Roalf, David R.University of Pennsylvania (author)
Sharma, VaishnaviUniversity of Pennsylvania (author)
Strain, Eric C.Johns Hopkins University School of Medicine (author)
Corder, GregoryUniversity of Pennsylvania (author)
Dworkin, Robert H.University of Rochester School of Medicine and Dentistry (author)
Satterthwaite, Theodore D.University of Pennsylvania (author)
University of PennsylvaniaKlinisk minnesforskning (creator_code:org_t)

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