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Predictive molecula...
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Malapelle, UmbertoUniversity of Naples Federico II
(author)
Predictive molecular pathology in the time of coronavirus disease (COVID-19) in Europe
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:38cadbef-5a6d-4580-9c1d-1bcda92282df
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https://lup.lub.lu.se/record/38cadbef-5a6d-4580-9c1d-1bcda92282dfURI
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https://doi.org/10.1136/jclinpath-2020-206957DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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Aims Lung cancer predictive biomarker testing is essential to select advanced-stage patients for targeted treatments and should be carried out without delays even during health emergencies, such as the coronavirus (COVID-19) outbreak. Methods Fifteen molecular laboratories from seven different European countries compared 4 weeks of national lockdown to a corresponding period in 2019, in terms of tissue and/or plasma-based molecular test workload, analytical platforms adopted, number of cases undergoing programmed death-ligand1 (PD-L1) expression assessment and DNA-based molecular tests turnaround time. Results In most laboratories (80.0%), tissue-based molecular test workload was reduced. In 40.0% of laboratories (6/15), the decrease was >25%, and in one, reduction was as high as 80.0%. In this instance, a concomitant increase in liquid biopsy was reported (60.0%). Remarkably, in 33.3% of the laboratories, real-time PCR (RT-PCR)-based methodologies increased, whereas highly multiplexing assays approaches decreased. Most laboratories (88.9%) did not report significant variations in PD-L1 volume testing. Conclusions The workload of molecular testing for patients with advanced-stage lung cancer during the lockdown showed little variations. Local strategies to overcome health emergency-related issues included the preference for RT-PCR tissue-based testing methodologies and, occasionally, for liquid biopsy.
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Pisapia, PasqualeUniversity of Naples Federico II
(author)
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Iaccarino, AntoninoUniversity of Naples Federico II
(author)
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Barberis, MassimoEuropean Institute of Oncology
(author)
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Bellevicine, ClaudioUniversity of Naples Federico II
(author)
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Brunnström, HansLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-hsb
(author)
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de Biase, DarioUniversity of Bologna
(author)
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de Maglio, GiovannaUniversity Hospital of Udine
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Lindquist, Kajsa EricsonLund University,Lunds universitet,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-ker
(author)
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Fassan, MatteoUniversity of Padova
(author)
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Fontanini, GabriellaUniversity of Pisa
(author)
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Gruppioni, ElisaUniversity of Bologna
(author)
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Hofman, PaulInstitut Gustave Roussy
(author)
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Merkelbach-Bruse, SabineUniversity Hospital of Cologne
(author)
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Molina Vila, Miguel A.Pangaea Oncology
(author)
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Pujals, AnaïsHenri Mondor Hospital
(author)
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Rapa, IdaSan Luigi University Hospital
(author)
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Righi, LuisellaUniversity of Turin
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Rosell, RafaelHospital Universitari Germans Trias i Pujol
(author)
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Schildgen, OliverWitten/Herdecke University
(author)
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Schildgen, VerenaWitten/Herdecke University
(author)
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Schmitt, Fernando C.University of Porto
(author)
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Tallini, GiovanniUniversity of Bologna
(author)
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Borght, Sara VanderUniversity Hospitals Leuven
(author)
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Vigliar, ElenaUniversity of Naples Federico II
(author)
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Volante, MarcoUniversity of Turin
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Wagener-Ryczek, SvenjaUniversity Hospital of Cologne
(author)
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Weynand, BirgitUniversity Hospitals Leuven
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Troncone, GiancarloUniversity of Naples Federico II
(author)
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University of Naples Federico IIEuropean Institute of Oncology
(creator_code:org_t)
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In:Journal of Clinical Pathology: BMJ74:6, s. 391-3950021-97461472-4146
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Malapelle, Umber ...
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Pisapia, Pasqual ...
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Iaccarino, Anton ...
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Barberis, Massim ...
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Bellevicine, Cla ...
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Brunnström, Hans
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de Biase, Dario
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de Maglio, Giova ...
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Fassan, Matteo
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Fontanini, Gabri ...
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Gruppioni, Elisa
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Hofman, Paul
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Merkelbach-Bruse ...
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Molina Vila, Mig ...
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Pujals, Anaïs
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Rapa, Ida
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Righi, Luisella
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Rosell, Rafael
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Schildgen, Olive ...
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Schildgen, Veren ...
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Schmitt, Fernand ...
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Tallini, Giovann ...
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Borght, Sara Van ...
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Vigliar, Elena
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Volante, Marco
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Weynand, Birgit
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