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Multiple Associated Variants Increase the Heritability Explained for Plasma Lipids and Coronary Artery Disease.
- Tada, Hayato (author)
- Won, Hong-Hee (author)
-
- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Yang, Jian (author)
- Peloso, Gina M (author)
- Kathiresan, Sekar (author)
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- (creator_code:org_t)
- 2014
- 2014
- English.
- In: Circulation: Cardiovascular Genetics. - 1942-325X. ; 7:5, s. 583-587
- Journal article (peer-reviewed)
Abstract
Subject headings
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- -Plasma lipid levels as well as coronary artery disease (CAD) have been shown to be highly heritable with estimates ranging from 40%-60%. However, top variants detected by large-scale genome-wide association studies (GWAS) explain only a fraction of the total variance in plasma lipid phenotypes and CAD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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