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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 12713naa a2202833 4500 | |
| 001 | oai:lup.lub.lu.se:39d7324c-c993-4e43-8c53-4ed4938e0a3f | |
| 003 | SwePub | |
| 008 | 160401s2011 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-47495 | |
| 009 | oai:prod.swepub.kib.ki.se:122989504 | |
| 009 | oai:DiVA.org:uu-157010 | |
| 024 | 7 | a https://lup.lub.lu.se/record/20721462 URI |
| 024 | 7 | a https://doi.org/10.1093/hmg/ddr2262 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-474952 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1229895042 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1570102 URI |
| 040 | a (SwePub)lud (SwePub)umud (SwePub)kid (SwePub)uu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Antoniou, Antonis C.4 aut |
| 245 | 1 0 | a Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers |
| 264 | c 2011-05-18 | |
| 264 | 1 | b Oxford University Press (OUP),c 2011 |
| 520 | a Two single nucleotide polymorphisms (SNPs) at 6q25.1, near the ESR1 gene, have been implicated in the susceptibility to breast cancer for Asian (rs2046210) and European women (rs9397435). A genome-wide association study in Europeans identified two further breast cancer susceptibility variants: rs11249433 at 1p11.2 and rs999737 in RAD51L1 at 14q24.1. Although previously identified breast cancer susceptibility variants have been shown to be associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers, the involvement of these SNPs to breast cancer susceptibility in mutation carriers is currently unknown. To address this, we genotyped these SNPs in BRCA1 and BRCA2 mutation carriers from 42 studies from the Consortium of Investigators of Modifiers of BRCA1/2. In the analysis of 14 123 BRCA1 and 8053 BRCA2 mutation carriers of European ancestry, the 6q25.1 SNPs (r(2) = 0.14) were independently associated with the risk of breast cancer for BRCA1 mutation carriers [ hazard ratio (HR) = 1.17, 95% confidence interval (CI): 1.11-1.23, P-trend = 4.5 x 10(-9) for rs2046210; HR = 1.28, 95% CI: 1.18-1.40, P-trend = 1.3 x 10(-8) for rs9397435], but only rs9397435 was associated with the risk for BRCA2 carriers (HR = 1.14, 95% CI: 1.01-1.28, P-trend = 0.031). SNP rs11249433 (1p11.2) was associated with the risk of breast cancer for BRCA2 mutation carriers (HR = 1.09, 95% CI: 1.02-1.17, P-trend = 0.015), but was not associated with breast cancer risk for BRCA1 mutation carriers (HR = 0.97, 95% CI: 0.92-1.02, P-trend = 0.20). SNP rs999737 (RAD51L1) was not associated with breast cancer risk for either BRCA1 or BRCA2 mutation carriers (P-trend = 0.27 and 0.30, respectively). The identification of SNPs at 6q25.1 associated with breast cancer risk for BRCA1 mutation carriers will lead to a better understanding of the biology of tumour development in these women. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Genetic Predisposition to Disease | |
| 653 | a Female | |
| 653 | a Pair 6 | |
| 653 | a Pair 1 | |
| 653 | a Human | |
| 653 | a Chromosomes | |
| 653 | a Breast Neoplasms | |
| 653 | a BRCA2 Protein | |
| 653 | a BRCA1 Protein | |
| 653 | a Alleles | |
| 653 | a Adult | |
| 653 | a Aged | |
| 653 | a Heterozygote | |
| 653 | a Humans | |
| 653 | a Middle Aged | |
| 653 | a Mutation | |
| 653 | a Polymorphism | |
| 653 | a Single Nucleotide | |
| 653 | a Risk Factors | |
| 653 | a MEDICINE | |
| 700 | 1 | a Kartsonaki, Christiana4 aut |
| 700 | 1 | a Sinilnikova, Olga M.4 aut |
| 700 | 1 | a Soucy, Penny4 aut |
| 700 | 1 | a McGuffog, Lesley4 aut |
| 700 | 1 | a Healey, Sue4 aut |
| 700 | 1 | a Lee, Andrew4 aut |
| 700 | 1 | a Peterlongo, Paolo4 aut |
| 700 | 1 | a Manoukian, Siranoush4 aut |
| 700 | 1 | a Peissel, Bernard4 aut |
| 700 | 1 | a Zaffaroni, Daniela4 aut |
| 700 | 1 | a Cattaneo, Elisa4 aut |
| 700 | 1 | a Barile, Monica4 aut |
| 700 | 1 | a Pensotti, Valeria4 aut |
| 700 | 1 | a Pasini, Barbara4 aut |
| 700 | 1 | a Dolcetti, Riccardo4 aut |
| 700 | 1 | a Giannini, Giuseppe4 aut |
| 700 | 1 | a Putignano, Anna Laura4 aut |
| 700 | 1 | a Varesco, Liliana4 aut |
| 700 | 1 | a Radice, Paolo4 aut |
| 700 | 1 | a Mai, Phuong L.4 aut |
| 700 | 1 | a Greene, Mark H.4 aut |
| 700 | 1 | a Andrulis, Irene L.u Karolinska Institutet4 aut |
| 700 | 1 | a Glendon, Gord4 aut |
| 700 | 1 | a Ozcelik, Hilmi4 aut |
| 700 | 1 | a Thomassen, Mads4 aut |
| 700 | 1 | a Gerdes, Anne-Marie4 aut |
| 700 | 1 | a Kruse, Torben A.4 aut |
| 700 | 1 | a Jensen, Uffe Birk4 aut |
| 700 | 1 | a Crueger, Dorthe G.4 aut |
| 700 | 1 | a Caligo, Maria A.4 aut |
| 700 | 1 | a Laitman, Yael4 aut |
| 700 | 1 | a Milgrom, Roni4 aut |
| 700 | 1 | a Kaufman, Bella4 aut |
| 700 | 1 | a Paluch-Shimon, Shani4 aut |
| 700 | 1 | a Friedman, Eitan4 aut |
| 700 | 1 | a Loman, Niklasu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-nlo |
| 700 | 1 | a Harbst, Katjau Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-kbn |
| 700 | 1 | a Lindblom, Annika4 aut |
| 700 | 1 | a Arver, Britau Karolinska Institutet4 aut |
| 700 | 1 | a Ehrencrona, Hansu Uppsala universitet,Medicinsk genetik4 aut0 (Swepub:uu)habos227 |
| 700 | 1 | a Melin, Beatriceu Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010 |
| 700 | 1 | a Nathanson, Katherine L.4 aut |
| 700 | 1 | a Domchek, Susan M.4 aut |
| 700 | 1 | a Rebbeck, Timothy4 aut |
| 700 | 1 | a Jakubowska, Ania4 aut |
| 700 | 1 | a Lubinski, Jan4 aut |
| 700 | 1 | a Gronwald, Jacek4 aut |
| 700 | 1 | a Huzarski, Tomasz4 aut |
| 700 | 1 | a Byrski, Tomasz4 aut |
| 700 | 1 | a Cybulski, Cezary4 aut |
| 700 | 1 | a Gorski, Bohdan4 aut |
| 700 | 1 | a Osorio, Ana4 aut |
| 700 | 1 | a Ramon y Cajal, Teresa4 aut |
| 700 | 1 | a Fostira, Florentia4 aut |
| 700 | 1 | a Andres, Raquel4 aut |
| 700 | 1 | a Benitez, Javier4 aut |
| 700 | 1 | a Hamann, Ute4 aut |
| 700 | 1 | a Hogervorst, Frans B.4 aut |
| 700 | 1 | a Rookus, Matti A.4 aut |
| 700 | 1 | a Hooning, Maartje J.4 aut |
| 700 | 1 | a Nelen, Marcel R.4 aut |
| 700 | 1 | a van der Luijt, Rob B.4 aut |
| 700 | 1 | a van Os, Theo A. M.4 aut |
| 700 | 1 | a van Asperen, Christi J.4 aut |
| 700 | 1 | a Devilee, Peter4 aut |
| 700 | 1 | a Meijers-Heijboer, Hanne E. J.4 aut |
| 700 | 1 | a Garcia, Encarna B. Gomez4 aut |
| 700 | 1 | a Peock, Susan4 aut |
| 700 | 1 | a Cook, Margaret4 aut |
| 700 | 1 | a Frost, Debra4 aut |
| 700 | 1 | a Platte, Radka4 aut |
| 700 | 1 | a Leyland, Jean4 aut |
| 700 | 1 | a Evans, D. Gareth4 aut |
| 700 | 1 | a Lalloo, Fiona4 aut |
| 700 | 1 | a Eeles, Ros4 aut |
| 700 | 1 | a Izatt, Louise4 aut |
| 700 | 1 | a Adlard, Julian4 aut |
| 700 | 1 | a Davidson, Rosemarie4 aut |
| 700 | 1 | a Eccles, Diana4 aut |
| 700 | 1 | a Ong, Kai-ren4 aut |
| 700 | 1 | a Cook, Jackie4 aut |
| 700 | 1 | a Douglas, Fiona4 aut |
| 700 | 1 | a Paterson, Joan4 aut |
| 700 | 1 | a Kennedy, M. John4 aut |
| 700 | 1 | a Miedzybrodzka, Zosia4 aut |
| 700 | 1 | a Godwin, Andrew4 aut |
| 700 | 1 | a Stoppa-Lyonnet, Dominique4 aut |
| 700 | 1 | a Buecher, Bruno4 aut |
| 700 | 1 | a Belotti, Muriel4 aut |
| 700 | 1 | a Tirapo, Carole4 aut |
| 700 | 1 | a Mazoyer, Sylvie4 aut |
| 700 | 1 | a Barjhoux, Laure4 aut |
| 700 | 1 | a Lasset, Christine4 aut |
| 700 | 1 | a Leroux, Dominique4 aut |
| 700 | 1 | a Faivre, Laurence4 aut |
| 700 | 1 | a Bronner, Myriam4 aut |
| 700 | 1 | a Prieur, Fabienne4 aut |
| 700 | 1 | a Nogues, Catherine4 aut |
| 700 | 1 | a Rouleau, Etienne4 aut |
| 700 | 1 | a Pujol, Pascal4 aut |
| 700 | 1 | a Coupier, Isabelle4 aut |
| 700 | 1 | a Frenay, Marc4 aut |
| 700 | 1 | a Hopper, John L.4 aut |
| 700 | 1 | a Daly, Mary B.4 aut |
| 700 | 1 | a Terry, Mary B.4 aut |
| 700 | 1 | a John, Esther M.4 aut |
| 700 | 1 | a Buys, Saundra S.4 aut |
| 700 | 1 | a Yassin, Yosuf4 aut |
| 700 | 1 | a Miron, Alexander4 aut |
| 700 | 1 | a Goldgar, David4 aut |
| 700 | 1 | a Singer, Christian F.4 aut |
| 700 | 1 | a Tea, Muy-Kheng4 aut |
| 700 | 1 | a Pfeiler, Georg4 aut |
| 700 | 1 | a Dressler, Anne Catharina4 aut |
| 700 | 1 | a Hansen, Thomas v. O.4 aut |
| 700 | 1 | a Jonson, Lars4 aut |
| 700 | 1 | a Ejlertsen, Bent4 aut |
| 700 | 1 | a Barkardottir, Rosa Bjork4 aut |
| 700 | 1 | a Kirchhoff, Tomas4 aut |
| 700 | 1 | a Offit, Kenneth4 aut |
| 700 | 1 | a Piedmonte, Marion4 aut |
| 700 | 1 | a Rodriguez, Gustavo4 aut |
| 700 | 1 | a Small, Laurie4 aut |
| 700 | 1 | a Boggess, John4 aut |
| 700 | 1 | a Blank, Stephanie4 aut |
| 700 | 1 | a Basil, Jack4 aut |
| 700 | 1 | a Azodi, Masoud4 aut |
| 700 | 1 | a Toland, Amanda Ewart4 aut |
| 700 | 1 | a Montagna, Marco4 aut |
| 700 | 1 | a Tognazzo, Silvia4 aut |
| 700 | 1 | a Agata, Simona4 aut |
| 700 | 1 | a Imyanitov, Evgeny4 aut |
| 700 | 1 | a Janavicius, Ramunas4 aut |
| 700 | 1 | a Lazaro, Conxi4 aut |
| 700 | 1 | a Blanco, Ignacio4 aut |
| 700 | 1 | a Pharoah, Paul D. P.4 aut |
| 700 | 1 | a Sucheston, Lara4 aut |
| 700 | 1 | a Karlan, Beth Y.4 aut |
| 700 | 1 | a Walsh, Christine S.4 aut |
| 700 | 1 | a Olah, Edith4 aut |
| 700 | 1 | a Bozsik, Aniko4 aut |
| 700 | 1 | a Teo, Soo-Hwang4 aut |
| 700 | 1 | a Seldon, Joyce L.4 aut |
| 700 | 1 | a Beattie, Mary S.4 aut |
| 700 | 1 | a van Rensburg, Elizabeth J.4 aut |
| 700 | 1 | a Sluiter, Michelle D.4 aut |
| 700 | 1 | a Diez, Orland4 aut |
| 700 | 1 | a Schmutzler, Rita K.4 aut |
| 700 | 1 | a Wappenschmidt, Barbara4 aut |
| 700 | 1 | a Engel, Christoph4 aut |
| 700 | 1 | a Meindl, Alfons4 aut |
| 700 | 1 | a Ruehl, Ina4 aut |
| 700 | 1 | a Varon-Mateeva, Raymonda4 aut |
| 700 | 1 | a Kast, Karin4 aut |
| 700 | 1 | a Deissler, Helmut4 aut |
| 700 | 1 | a Niederacher, Dieter4 aut |
| 700 | 1 | a Arnold, Norbert4 aut |
| 700 | 1 | a Gadzicki, Dorothea4 aut |
| 700 | 1 | a Schoenbuchner, Ines4 aut |
| 700 | 1 | a Caldes, Trinidad4 aut |
| 700 | 1 | a de la Hoya, Miguel4 aut |
| 700 | 1 | a Nevanlinna, Heli4 aut |
| 700 | 1 | a Aittomaki, Kristiina4 aut |
| 700 | 1 | a Dumont, Martine4 aut |
| 700 | 1 | a Chiquette, Jocelyne4 aut |
| 700 | 1 | a Tischkowitz, Marc4 aut |
| 700 | 1 | a Chen, Xiaoqing4 aut |
| 700 | 1 | a Beesley, Jonathan4 aut |
| 700 | 1 | a Spurdle, Amanda B.4 aut |
| 700 | 1 | a Neuhausen, Susan L.4 aut |
| 700 | 1 | a Ding, Yuan Chun4 aut |
| 700 | 1 | a Fredericksen, Zachary4 aut |
| 700 | 1 | a Wang, Xianshu4 aut |
| 700 | 1 | a Pankratz, Vernon S.4 aut |
| 700 | 1 | a Couch, Fergus4 aut |
| 700 | 1 | a Simard, Jacques4 aut |
| 700 | 1 | a Easton, Douglas F.4 aut |
| 700 | 1 | a Chenevix-Trench, Georgia4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups4 aut0 (Swepub:lu)onk-abo |
| 700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)onk-hol |
| 710 | 2 | a Karolinska Institutetb Bröstcancer-genetik4 org |
| 773 | 0 | t Human Molecular Geneticsd : Oxford University Press (OUP)g 20:16, s. 3304-3321q 20:16<3304-3321x 0964-6906x 1460-2083 |
| 856 | 4 | u http://dx.doi.org/10.1093/hmg/ddr226x freey FULLTEXT |
| 856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/21593217x freey FULLTEXT |
| 856 | 4 | u http://dx.doi.org/10.1093/hmg/ddr226y FULLTEXT |
| 856 | 4 | u https://academic.oup.com/hmg/article-pdf/20/16/3304/17252236/ddr226.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2072146 |
| 856 | 4 8 | u https://doi.org/10.1093/hmg/ddr226 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-47495 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122989504 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-157010 |
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