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In search of enviro...
In search of environmental risk factors for obsessive-compulsive disorder : study protocol for the OCDTWIN project
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- Mataix-Cols, David (author)
- Karolinska Institutet,Karolinska Institute,Lund University,Lunds universitet,Innovations in pediatric mental health,Forskargrupper vid Lunds universitet,Lund University Research Groups,Stockholms läns sjukvårdsområde
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- Fernández de la Cruz, Lorena (author)
- Karolinska Institutet,Karolinska Institute
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- De Schipper, Elles (author)
- Karolinska Institutet,Karolinska Institute
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- Kuja-Halkola, Ralf (author)
- Karolinska Institutet,Karolinska Institute
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- Bulik, Cynthia M. (author)
- Karolinska Institutet,Karolinska Institute,University of North Carolina
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- Crowley, James J. (author)
- Karolinska Institute,University of North Carolina
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- Neufeld, Janina (author)
- Karolinska Institutet,Karolinska Institute
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- Rück, Christian (author)
- Karolinska Institutet,Karolinska Institute
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- Tammimies, Kristiina (author)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital
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- Lichtenstein, Paul (author)
- Karolinska Institutet,Karolinska Institute
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- Bölte, Sven (author)
- Karolinska Institutet,Karolinska Institute,Curtin University
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- Beucke, Jan C. (author)
- Karolinska Institute,Humboldt University of Berlin
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(creator_code:org_t)
- 2023
- 2023
- English.
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In: BMC Psychiatry. - 1471-244X. ; 23:1
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Abstract
Subject headings
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- Background: The causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of environmental risk factors is at least as important and should be a priority because some of them may be amenable to prevention or early intervention strategies. Genetically informative studies, particularly those employing the discordant monozygotic (MZ) twin design, are ideally suited to study environmental risk factors. This protocol paper describes the study rationale, aims, and methods of OCDTWIN, an open cohort of MZ twin pairs who are discordant for the diagnosis of OCD. Methods: OCDTWIN has two broad aims. In Aim 1, we are recruiting MZ twin pairs from across Sweden, conducting thorough clinical assessments, and building a biobank of biological specimens, including blood, saliva, urine, stool, hair, nails, and multimodal brain imaging. A wealth of early life exposures (e.g., perinatal variables, health-related information, psychosocial stressors) are available through linkage with the nationwide registers and the Swedish Twin Registry. Blood spots stored in the Swedish phenylketonuria (PKU) biobank will be available to extract DNA, proteins, and metabolites, providing an invaluable source of biomaterial taken at birth. In Aim 2, we will perform within-pair comparisons of discordant MZ twins, which will allow us to isolate unique environmental risk factors that are in the causal pathway to OCD, while strictly controlling for genetic and early shared environmental influences. To date (May 2023), 43 pairs of twins (21 discordant for OCD) have been recruited. Discussion: OCDTWIN hopes to generate unique insights into environmental risk factors that are in the causal pathway to OCD, some of which have the potential of being actionable targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Discordant twins
- Early intervention
- Environmental risk factors
- Monozygotic twins
- Obsessive-compulsive disorder
- Prevention
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Mataix-Cols, Dav ...
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Fernández de la ...
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De Schipper, Ell ...
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Kuja-Halkola, Ra ...
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Bulik, Cynthia M ...
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Crowley, James J ...
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show more...
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Neufeld, Janina
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Rück, Christian
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Tammimies, Krist ...
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Lichtenstein, Pa ...
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Bölte, Sven
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Beucke, Jan C.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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BMC Psychiatry
- By the university
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Lund University
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Karolinska Institutet