Search: onr:"swepub:oai:lup.lub.lu.se:3a276696-71b1-405d-887f-b74233425358" >
The Life History of...
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Nik-Zainal, Serena
(author)
The Life History of 21 Breast Cancers
- Article/chapterEnglish2012
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:3a276696-71b1-405d-887f-b74233425358
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https://lup.lub.lu.se/record/2906918URI
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https://doi.org/10.1016/j.cell.2012.04.023DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Cancer evolves dynamically as clonal expansions supersede one another driven by shifting selective pressures, mutational processes, and disrupted cancer genes. These processes mark the genome, such that a cancer's life history is encrypted in the somatic mutations present. We developed algorithms to decipher this narrative and applied them to 21 breast cancers. Mutational processes evolve across a cancer's lifespan, with many emerging late but contributing extensive genetic variation. Subclonal diversification is prominent, and most mutations are found in just a fraction of tumor cells. Every tumor has a dominant subclonal lineage, representing more than 50% of tumor cells. Minimal expansion of these subclones occurs until many hundreds to thousands of mutations have accumulated, implying the existence of long-lived, quiescent cell lineages capable of substantial proliferation upon acquisition of enabling genomic changes. Expansion of the dominant subclone to an appreciable mass may therefore represent the final rate-limiting step in a breast cancer's development, triggering diagnosis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Van Loo, Peter
(author)
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Wedge, David C.
(author)
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Alexandrov, Ludmil B.
(author)
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Greenman, Christopher D.
(author)
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Lau, King Wai
(author)
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Raine, Keiran
(author)
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Jones, David
(author)
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Marshall, John
(author)
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Ramakrishna, Manasa
(author)
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Shlien, Adam
(author)
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Cooke, Susanna L.
(author)
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Hinton, Jonathan
(author)
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Menzies, Andrew
(author)
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Stebbings, Lucy A.
(author)
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Leroy, Catherine
(author)
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Jia, Mingming
(author)
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Rance, Richard
(author)
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Mudie, Laura J.
(author)
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Gamble, Stephen J.
(author)
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Stephens, Philip J.
(author)
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McLaren, Stuart
(author)
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Tarpey, Patrick S.
(author)
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Papaemmanuil, Elli
(author)
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Davies, Helen R.
(author)
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Varela, Ignacio
(author)
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McBride, David J.
(author)
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Bignell, Graham R.
(author)
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Leung, Kenric
(author)
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Butler, Adam P.
(author)
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Teague, Jon W.
(author)
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Martin, Sancha
(author)
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Joensson, Goran
(author)
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Mariani, Odette
(author)
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Boyault, Sandrine
(author)
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Miron, Penelope
(author)
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Fatima, Aquila
(author)
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Langerod, Anita
(author)
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Aparicio, Samuel A. J. R.
(author)
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Tutt, Andrew
(author)
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Sieuwerts, Anieta M.
(author)
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Borg, ÅkeLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-abo
(author)
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Thomas, Gilles
(author)
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Salomon, Anne Vincent
(author)
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Richardson, Andrea L.
(author)
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Borresen-Dale, Anne-Lise
(author)
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Futreal, P. Andrew
(author)
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Stratton, Michael R.
(author)
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Campbell, Peter J.
(author)
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Bröstcancer-genetikSektion I
(creator_code:org_t)
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In:Cell: Elsevier BV149:51097-41720092-8674
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Nik-Zainal, Sere ...
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Van Loo, Peter
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Wedge, David C.
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Alexandrov, Ludm ...
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Greenman, Christ ...
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Lau, King Wai
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Raine, Keiran
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Jones, David
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Marshall, John
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Shlien, Adam
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Hinton, Jonathan
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Menzies, Andrew
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Stebbings, Lucy ...
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Leroy, Catherine
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Jia, Mingming
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Mudie, Laura J.
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Gamble, Stephen ...
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Stephens, Philip ...
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McLaren, Stuart
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Tarpey, Patrick ...
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Papaemmanuil, El ...
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Davies, Helen R.
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Varela, Ignacio
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McBride, David J ...
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Bignell, Graham ...
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Leung, Kenric
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Butler, Adam P.
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Teague, Jon W.
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Martin, Sancha
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Joensson, Goran
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Mariani, Odette
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Boyault, Sandrin ...
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Miron, Penelope
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Fatima, Aquila
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Langerod, Anita
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Aparicio, Samuel ...
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Tutt, Andrew
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Sieuwerts, Aniet ...
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Borg, Åke
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Thomas, Gilles
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Salomon, Anne Vi ...
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Borresen-Dale, A ...
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Stratton, Michae ...
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Cell
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Lund University