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Genetic predisposit...
Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes
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- Dooley, James (author)
- Catholic University of Leuven
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- Tian, Lei (author)
- Catholic University of Leuven
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- Schonefeldt, Susann (author)
- Catholic University of Leuven
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- Delghingaro-Augusto, Viviane (author)
- Australian National University
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- Garcia-Perez, Josselyn E (author)
- Catholic University of Leuven
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- Pasciuto, Emanuela (author)
- Catholic University of Leuven
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- Di Marino, Daniele (author)
- Università della Svizzera Italiana
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- Carr, Edward J (author)
- Babraham Institute
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- Oskolkov, Nikolay (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Lyssenko, Valeriya (author)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups
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- Franckaert, Dean (author)
- Catholic University of Leuven
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Lagou, Vasiliki (author)
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Overbergh, Lut (author)
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Vandenbussche, Jonathan (author)
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Allemeersch, Joke (author)
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Chabot-Roy, Genevieve (author)
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Dahlstrom, Jane E (author)
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Laybutt, D Ross (author)
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Petrovsky, Nikolai (author)
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Socha, Luis (author)
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Gevaert, Kris (author)
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Jetten, Anton M (author)
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Lambrechts, Diether (author)
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Linterman, Michelle A (author)
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Goodnow, Chris C (author)
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Nolan, Christopher J (author)
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Lesage, Sylvie (author)
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Schlenner, Susan M (author)
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Liston, Adrian (author)
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(creator_code:org_t)
- 2016-03-21
- 2016
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 48, s. 519-527
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Abstract
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- Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell fragility. Genetic variation in Xrcc4 and Glis3 alters the response of NOD beta cells to unfolded protein stress, enhancing the apoptotic and senescent fates. The same transcriptional relationships were observed in human islets, demonstrating the role of beta cell fragility in genetic predisposition to diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Dooley, James
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Tian, Lei
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Schonefeldt, Sus ...
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Delghingaro-Augu ...
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Garcia-Perez, Jo ...
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Pasciuto, Emanue ...
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show more...
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Di Marino, Danie ...
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Carr, Edward J
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Oskolkov, Nikola ...
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Lyssenko, Valeri ...
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Franckaert, Dean
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Lagou, Vasiliki
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Overbergh, Lut
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Vandenbussche, J ...
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Allemeersch, Jok ...
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Chabot-Roy, Gene ...
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Dahlstrom, Jane ...
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Laybutt, D Ross
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Petrovsky, Nikol ...
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Socha, Luis
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Gevaert, Kris
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Jetten, Anton M
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Lambrechts, Diet ...
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Linterman, Miche ...
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Goodnow, Chris C
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Nolan, Christoph ...
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Lesage, Sylvie
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Schlenner, Susan ...
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Liston, Adrian
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Genetics
- By the university
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Lund University