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Protein Quality Con...
Protein Quality Control Pathways at the Crossroad of Synucleinopathies
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- De Mattos, Eduardo P. (author)
- University Medical Center Groningen,University of Groningen
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- Wentink, Anne (author)
- German Cancer Research Centre,Heidelberg University
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- Nussbaum-Krammer, Carmen (author)
- German Cancer Research Centre,Heidelberg University
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- Hansen, Christian (author)
- Lund University,Lunds universitet,Molekylär neurobiologi,Forskargrupper vid Lunds universitet,Molecular Neurobiology,Lund University Research Groups
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- Bergink, Steven (author)
- University Medical Center Groningen
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- Melki, Ronald (author)
- François Jacob Institute of biology
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- Kampinga, Harm H. (author)
- University Medical Center Groningen
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(creator_code:org_t)
- 2020
- 2020
- English 14 s.
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In: Journal of Parkinson's Disease. - 1877-7171. ; 10:2, s. 369-382
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Abstract
Subject headings
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- The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (α-Syn) aggregation. Although it is still not entirely clear what precise biophysical processes act as triggers, cumulative evidence points towards a crucial role for protein quality control (PQC) systems in modulating α-Syn aggregation and toxicity. These encompass distinct cellular strategies that tightly balance protein production, stability, and degradation, ultimately regulating α-Syn levels. Here, we review the main aspects of α-Syn biology, focusing on the cellular PQC components that are at the heart of recognizing and disposing toxic, aggregate-prone α-Syn assemblies: molecular chaperones and the ubiquitin-proteasome system and autophagy-lysosome pathway, respectively. A deeper understanding of these basic protein homeostasis mechanisms might contribute to the development of new therapeutic strategies envisioning the prevention and/or enhanced degradation of α-Syn aggregates.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Keyword
- Alpha-synuclein
- autophagy
- molecular chaperones
- protein aggregation
- protein homeostasis
- synucleinopathies
- ubiquitin-proteasome system
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