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Discriminative accu...
Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease
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- Pascoal, Tharick A. (author)
- University of Pittsburgh,McGill University Research Centre for Studies in Aging
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- Leuzy, Antoine (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Therriault, Joseph (author)
- Montreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
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- Chamoun, Mira (author)
- Montreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
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- Lussier, Firoza (author)
- University of Pittsburgh,McGill University Research Centre for Studies in Aging
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- Tissot, Cecile (author)
- Lund University,University of Pittsburgh
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- Strandberg, Olof (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Palmqvist, Sebastian (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Stomrud, Erik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Ferreira, Pamela C.L. (author)
- University of Pittsburgh
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- Ferrari-Souza, João Pedro (author)
- University of Pittsburgh,Federal University of Rio Grande do Sul
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- Smith, Ruben (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Regeneration in Movement Disorders,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Benedet, Andrea Lessa (author)
- McGill University Research Centre for Studies in Aging,Montreal Neurological Institute & Hospital
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- Gauthier, Serge (author)
- McGill University Research Centre for Studies in Aging
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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- Rosa-Neto, Pedro (author)
- Montreal Neurological Institute & Hospital,McGill University Research Centre for Studies in Aging
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(creator_code:org_t)
- 2023-01-30
- 2023
- English.
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In: Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. - : Wiley. - 2352-8729. ; 15:1
- Related links:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- A/T/N system
- Alzheimer's disease
- biomarker
- diagnose
- PET
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Pascoal, Tharick ...
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Leuzy, Antoine
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Therriault, Jose ...
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Chamoun, Mira
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Lussier, Firoza
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Tissot, Cecile
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show more...
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Strandberg, Olof
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Palmqvist, Sebas ...
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Stomrud, Erik
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Ferreira, Pamela ...
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Ferrari-Souza, J ...
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Smith, Ruben
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Benedet, Andrea ...
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Gauthier, Serge
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Hansson, Oskar
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Rosa-Neto, Pedro
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University