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αvβ8 integrin-expre...
αvβ8 integrin-expression by BATF3-dependent dendritic cells facilitates early IgA responses to Rotavirus
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- Nakawesi, J (author)
- Lund University,Lunds universitet,Virusrekognition,Forskargrupper vid Lunds universitet,Virus Recognition,Lund University Research Groups
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- This, S (author)
- Claude Bernard University Lyon 1
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- Hütter, J (author)
- Berlin Institute of Health (BIH)
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- Boucard-Jourdin, M (author)
- Claude Bernard University Lyon 1
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- Barateau, V (author)
- Claude Bernard University Lyon 1
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- Muleta, K Getachew (author)
- Lund University
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- Gooday, L J (author)
- Lund University
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- Thomsen, K Fog (author)
- Technical University of Denmark
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- López, A Garcias (author)
- Technical University of Denmark
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- Ulmert, I (author)
- Technical University of Denmark
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- Poncet, D (author)
- University of Paris-Saclay
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- Malissen, B (author)
- Aix-Marseille University
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- Greenberg, H (author)
- VA Palo Alto Health Care System
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- Thaunat, O (author)
- Claude Bernard University Lyon 1
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- Defrance, T (author)
- Claude Bernard University Lyon 1
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- Paidassi, H (author)
- Claude Bernard University Lyon 1
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- Lahl, K (author)
- Lund University,Lunds universitet,Virusrekognition,Forskargrupper vid Lunds universitet,Virus Recognition,Lund University Research Groups,Technical University of Denmark
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
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In: Mucosal Immunology. - : Elsevier BV. - 1933-0219. ; 9:2, s. 53-67
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Abstract
Subject headings
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- Secretory intestinal IgA can protect from re-infection with rotavirus (RV), but very little is known about the mechanisms that induce IgA production during intestinal virus infections. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Here, we show that BATF3-dependent cDC1, but not cDC2, are critical for the optimal induction of RV-specific IgA responses in the mesenteric lymph nodes. This depends on the selective expression of the TGFβ-activating integrin αvβ8 by cDC1. In contrast, αvβ8 on cDC1 is dispensible for steady state immune homeostasis. Given that cDC2 are crucial in driving IgA during steady state but are dispensable for RV-specific IgA responses, we propose that the capacity of DC subsets to induce intestinal IgA responses reflects the context, as opposed to an intrinsic property of individual DC subsets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Nakawesi, J
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This, S
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Hütter, J
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Boucard-Jourdin, ...
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Barateau, V
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Muleta, K Getach ...
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show more...
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Gooday, L J
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Thomsen, K Fog
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López, A Garcias
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Ulmert, I
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Poncet, D
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Malissen, B
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Greenberg, H
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Thaunat, O
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Defrance, T
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Paidassi, H
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Lahl, K
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
- Articles in the publication
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Mucosal Immunolo ...
- By the university
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Lund University