Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritis : Results from the SWEFOT trial

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Hambardzumyan, KarenKarolinska University Hospital (author)

Serum biomarkers for prediction of response to methotrexate monotherapy in early rheumatoid arthritis : Results from the SWEFOT trial

Article/chapterEnglish2019

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2019-02-01
The Journal of Rheumatology,2019
9 s.

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LIBRIS-ID:oai:lup.lub.lu.se:3efc46dd-bbc8-4a57-94ec-42a781949adf
https://lup.lub.lu.se/record/3efc46dd-bbc8-4a57-94ec-42a781949adfURI
https://doi.org/10.3899/jrheum.180537DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:141041599URI

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Language:English
Summary in:English

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Subject category:ref swepub-contenttype

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Objective. To investigate baseline levels of 12 serum biomarkers that constitute a multibiomarker disease activity test, as predictors of response to methotrexate (MTX) in patients with early rheumatoid arthritis (eRA). Methods. In 298 patients from the Swedish Pharmacotherapy (SWEFOT) clinical trial, baseline serum levels of 12 proteins were analyzed for association with disease activity based on the 28-joint count Disease Activity Score (DAS28) after 3 months of MTX monotherapy using uni-/multivariate logistic regression. Primary outcome was low disease activity (LDA; DAS28 ≤ 3.2). Results. Of 298 patients, 104 achieved LDA after 3 months on MTX. Four of the 12 biomarkers [C-reactive protein (CRP), leptin, tumor necrosis factor receptor I (TNF-RI), and vascular cell adhesion molecule 1 (VCAM-1)] significantly predicted LDA based on stepwise logistic regression analysis. Dichotomization of patients using receiver-operating characteristic curve analysis-based cutoffs for these biomarkers showed significantly higher proportions with LDA among patients with lower versus higher levels of CRP or leptin (40% vs 23%, p = 0.004, and 40% vs 25%, p = 0.011, respectively), as well as among those with higher versus lower levels of TNF-RI or VCAM-1 (43% vs 27%, p = 0.004, and 41% vs 25%, p = 0.004, respectively). Combined score based on these biomarkers, adjusted for known predictors of LDA (smoking, sex, and age), associated with decreased chance of LDA (adjusted OR 0.45, 95% CI 0.32–0.62). Conclusion. Low baseline levels of CRP and leptin, and high baseline levels of TNF-RI and VCAM-1 were associated with LDA after 3 months of MTX therapy in patients with eRA. Combination of these 4 biomarkers increased accuracy of prediction.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Rheumatology and Autoimmunity hsv//eng
BIOMARKERS
METHOTREXATE RESPONSE
RHEUMATOID ARTHRITIS PREDICTION

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Bolce, Rebecca J.Lund University,Skåne University Hospital (author)
Wallman, Johan K.Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Arthritis Research Group (LARG),Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-jnk (author)
Van Vollenhoven, Ronald F.Karolinska Institutet,Karolinska Institute,Karolinska University Hospital (author)
Saevarsdottir, SaedisKarolinska Institutet,Karolinska Institute (author)
Karolinska University HospitalLund University (creator_code:org_t)

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In:Journal of Rheumatology: The Journal of Rheumatology46:6, s. 555-5630315-162X1499-2752

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