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Distinct tau PET pa...
Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease
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- Ossenkoppele, Rik (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Vrije Universiteit Amsterdam,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Lyoo, Chul Hyoung (author)
- Yonsei University,Severance Hospital
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- Sudre, Carole H. (author)
- King's College London,University College London
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- van Westen, Danielle (author)
- Lund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups
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- Cho, Hanna (author)
- Yonsei University,Severance Hospital
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- Ryu, Young Hoon (author)
- Yonsei University,Severance Hospital
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- Choi, Jae Yong (author)
- Korea Institute of Radiological & Medical Sciences (KIRAMS),Severance Hospital,Yonsei University
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- Smith, Ruben (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Strandberg, Olof (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Palmqvist, Sebastian (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups
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- Westman, Erik (author)
- Karolinska Institutet,Karolinska Institute
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- Tsai, Richard (author)
- University of California, San Francisco
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- Kramer, Joel (author)
- University of California, San Francisco
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- Boxer, Adam L. (author)
- Karolinska Institute
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- Gorno-Tempini, Maria L. (author)
- University of California, San Francisco
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- La Joie, Renaud (author)
- University of California, San Francisco
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- Miller, Bruce L. (author)
- University of California, San Francisco
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- Rabinovici, Gil D. (author)
- University of California, San Francisco
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- 2020-01-04
- 2020
- English 10 s.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 16:2, s. 335-344
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Abstract
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- Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Alzheimer's disease
- Atrophy
- Cognition
- Dementia
- Subtypes
- Tau
- Thickness
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Ossenkoppele, Ri ...
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Lyoo, Chul Hyoun ...
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Sudre, Carole H.
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van Westen, Dani ...
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Cho, Hanna
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Ryu, Young Hoon
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show more...
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Choi, Jae Yong
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Smith, Ruben
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Strandberg, Olof
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Palmqvist, Sebas ...
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Westman, Erik
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Tsai, Richard
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Kramer, Joel
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Boxer, Adam L.
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Gorno-Tempini, M ...
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La Joie, Renaud
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Miller, Bruce L.
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Rabinovici, Gil ...
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Hansson, Oskar
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University
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Karolinska Institutet