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Distinct tau PET pa...
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Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam
(author)
Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-01-04
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Wiley,2020
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10 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:3fd4cd77-1974-4a9b-b83a-89066d9a119f
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https://lup.lub.lu.se/record/3fd4cd77-1974-4a9b-b83a-89066d9a119fURI
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https://doi.org/10.1016/j.jalz.2019.08.201DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:143557439URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD.
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Lyoo, Chul HyoungYonsei University,Severance Hospital
(author)
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Sudre, Carole H.University College London,King's College London
(author)
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van Westen, DanielleLund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups(Swepub:lu)ront-dva
(author)
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Cho, HannaSeverance Hospital,Yonsei University
(author)
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Ryu, Young HoonSeverance Hospital,Yonsei University
(author)
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Choi, Jae YongKorea Institute of Radiological & Medical Sciences (KIRAMS),Severance Hospital,Yonsei University
(author)
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Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm
(author)
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Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn
(author)
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Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-spa
(author)
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Westman, ErikKarolinska Institutet,Karolinska Institute
(author)
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Tsai, RichardUniversity of California, San Francisco
(author)
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Kramer, JoelUniversity of California, San Francisco
(author)
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Boxer, Adam L.Karolinska Institute
(author)
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Gorno-Tempini, Maria L.University of California, San Francisco
(author)
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La Joie, RenaudUniversity of California, San Francisco
(author)
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Miller, Bruce L.University of California, San Francisco
(author)
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Rabinovici, Gil D.University of California, San Francisco
(author)
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Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn
(author)
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Klinisk minnesforskningForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:Alzheimer's and Dementia: Wiley16:2, s. 335-3441552-52601552-5279
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Ossenkoppele, Ri ...
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Lyoo, Chul Hyoun ...
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Sudre, Carole H.
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van Westen, Dani ...
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Cho, Hanna
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Ryu, Young Hoon
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Choi, Jae Yong
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Smith, Ruben
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Strandberg, Olof
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Palmqvist, Sebas ...
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Westman, Erik
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Tsai, Richard
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Kramer, Joel
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Boxer, Adam L.
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Gorno-Tempini, M ...
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La Joie, Renaud
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Miller, Bruce L.
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Rabinovici, Gil ...
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Hansson, Oskar
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