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Search: onr:"swepub:oai:lup.lub.lu.se:3fd4cd77-1974-4a9b-b83a-89066d9a119f" > Distinct tau PET pa...

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  • Ossenkoppele, RikLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Amsterdam UMC - Vrije Universiteit Amsterdam,Vrije Universiteit Amsterdam (author)

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • 2020-01-04
  • Wiley,2020
  • 10 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:3fd4cd77-1974-4a9b-b83a-89066d9a119f
  • https://lup.lub.lu.se/record/3fd4cd77-1974-4a9b-b83a-89066d9a119fURI
  • https://doi.org/10.1016/j.jalz.2019.08.201DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:143557439URI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) “typical”, (2) “limbic-predominant”, (3) “hippocampal-sparing”, and (4) “mild atrophy”. We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β–positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD.

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  • Lyoo, Chul HyoungYonsei University,Severance Hospital (author)
  • Sudre, Carole H.University College London,King's College London (author)
  • van Westen, DanielleLund University,Lunds universitet,Neuroradiologi,Forskargrupper vid Lunds universitet,Neuroradiology,Lund University Research Groups(Swepub:lu)ront-dva (author)
  • Cho, HannaSeverance Hospital,Yonsei University (author)
  • Ryu, Young HoonSeverance Hospital,Yonsei University (author)
  • Choi, Jae YongKorea Institute of Radiological & Medical Sciences (KIRAMS),Severance Hospital,Yonsei University (author)
  • Smith, RubenLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)mphy-rsm (author)
  • Strandberg, OlofLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)teor-osn (author)
  • Palmqvist, SebastianLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups(Swepub:lu)med-spa (author)
  • Westman, ErikKarolinska Institutet,Karolinska Institute (author)
  • Tsai, RichardUniversity of California, San Francisco (author)
  • Kramer, JoelUniversity of California, San Francisco (author)
  • Boxer, Adam L.Karolinska Institute (author)
  • Gorno-Tempini, Maria L.University of California, San Francisco (author)
  • La Joie, RenaudUniversity of California, San Francisco (author)
  • Miller, Bruce L.University of California, San Francisco (author)
  • Rabinovici, Gil D.University of California, San Francisco (author)
  • Hansson, OskarLund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)mphy-ohn (author)
  • Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Alzheimer's and Dementia: Wiley16:2, s. 335-3441552-52601552-5279

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