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- Brydegaard, MikkelLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University (author)
Photobleaching-Insensitive Fluorescence Diagnostics in Skin and Brain Tissue
- Article/chapterEnglish2011
Publisher, publication year, extent ...
- Institute of Electrical and Electronics Engineers,2011
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:3ffbaa10-9a9c-450c-bc40-a65ee2f389bd
- https://lup.lub.lu.se/record/1987844URI
- https://doi.org/10.1109/JPHOT.2011.2141656DOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-68345URI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- In this paper, we investigate the possibility of using accurate prediction models for the prediction of protoporphyrin bleaching dynamics to achieve photobleaching-insensitive methods to improve the evaluation of data in an existing clinical fluorescence-guided resection technique. To simulate the scenario, measurements were carried out in vivo on skin of healthy volunteers using a compact fiber-based fluorescence spectroscopy system. We have developed an effective method for the parameterization of sequences of bleaching spectra. We analyze convergence and decay rates with respect to initial conditions and excitation irradiance. We also discuss the consequences and the potential for bleaching-insensitive measurements and their applicability in a few examples from in vivo open brain surgery.
Subject headings and genre
- NATURVETENSKAP Fysik Atom- och molekylfysik och optik hsv//swe
- NATURAL SCIENCES Physical Sciences Atom and Molecular Physics and Optics hsv//eng
- Fluorescence-guided resection
- FGR
- 5-ALA
- PpIX
- protoporphyrin
- photobleaching
- laser-induced fluorescence spectroscopy
- LIF
- optical
- diagnostics
- tissue optics
- skin
- brain
- dynamic models
- system
- identification
- state space models
- Fluorescence-guided resection
- TECHNOLOGY
Added entries (persons, corporate bodies, meetings, titles ...)
- Haj-Hosseini, NedaLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT(Swepub:liu)nedha71 (author)
- Wårdell, KarinLinköpings universitet,Biomedicinsk instrumentteknik,Tekniska högskolan,MINT(Swepub:liu)karwa46 (author)
- Andersson-Engels, StefanLund University,Lunds universitet,Atomfysik,Fysiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Atomic Physics,Department of Physics,Departments at LTH,Faculty of Engineering, LTH,Department of Physics, Lund University(Swepub:lu)fysi-san (author)
- AtomfysikFysiska institutionen (creator_code:org_t)
Related titles
- In:IEEE Photonics Journal: Institute of Electrical and Electronics Engineers3:3, s. 407-4211943-0655
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