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MRI Characteristics...
MRI Characteristics of Pediatric Renal Tumors : A SIOP-RTSG Radiology Panel Delphi Study
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- van der Beek, Justine N. (author)
- Wilhelmina Children’s Hospital
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- Watson, Tom A. (author)
- Great Ormond Street Hospital
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- Nievelstein, Rutger A.J. (author)
- Wilhelmina Children’s Hospital
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- Brisse, Hervé J. (author)
- Curie Institute, Paris
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- Morosi, Carlo (author)
- Istituto Nazionale dei Tumori
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- Lederman, Henrique M. (author)
- Escola Paulista de Medicina
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- Coma, Ana (author)
- Vall d'Hebron University Hospital
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- Gavra, Maria M. (author)
- Aghia Sophia Children's Hospital
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- Vult von Steyern, Kristina (author)
- Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Lakatos, Karoly (author)
- Medical University of Vienna
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- Breysem, Luc (author)
- University Hospitals Leuven
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- Varga, Edit (author)
- Semmelweis University
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- Ducou Le Pointe, Hubert (author)
- Hôpital Armand Trousseau
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- Lequin, Maarten H. (author)
- Wilhelmina Children’s Hospital
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- Schäfer, Jürgen F. (author)
- University Hospital of Tubingen
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- Mentzel, Hans Joachim (author)
- Universitätsklinikum Jena
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- Hötker, Andreas M. (author)
- University Hospital of Zurich
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- Calareso, Giuseppina (author)
- Istituto Nazionale dei Tumori
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- Swinson, Sophie (author)
- Leeds Teaching Hospitals NHS Trust
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- Kyncl, Martin (author)
- University Hospital Motol
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- Granata, Claudio (author)
- Burlo Garofolo Pediatric Institute
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- Aertsen, Michael (author)
- University Hospitals Leuven
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- Di Paolo, Pier Luigi (author)
- Bambino Gesù Children’s Hospital
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- de Krijger, Ronald R. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology,University Medical Center Utrecht
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- Graf, Norbert (author)
- Saarland University Hospital
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- Olsen, Øystein E. (author)
- Great Ormond Street Hospital
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- Schenk, Jens Peter (author)
- University Hospital Heidelberg
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- van den Heuvel-Eibrink, Marry M. (author)
- Princess Maxima Center for Pediatric Oncology/Hematology
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- Littooij, Annemieke S. (author)
- Wilhelmina Children’s Hospital
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(creator_code:org_t)
- 2021-08-06
- 2022
- English.
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In: Journal of Magnetic Resonance Imaging. - : Wiley. - 1053-1807 .- 1522-2586. ; 55:2, s. 543-552
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Abstract
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- Background: The SIOP-Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis-based treatment initiation, but only for a relatively small percentage of approximately 10% of non-Wilms tumors (non-WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating characteristics. Purpose: To identify MRI characteristics that may be used for discrimination of newly diagnosed pediatric renal tumors. Study Type: Consensus process using a Delphi method. Population: Not applicable. Field Strength/Sequence: Abdominal MRI including T1- and T2-weighted imaging, contrast-enhanced MRI, and diffusion-weighted imaging at 1.5 or 3 T. Assessment: Twenty-three radiologists from the SIOP-RTSG radiology panel with ≥5 years of experience in MRI of pediatric renal tumors and/or who had assessed ≥50 MRI scans of pediatric renal tumors in the past 5 years identified potentially discriminatory characteristics in the first questionnaire. These characteristics were scored in the subsequent second round, consisting of 5-point Likert scales, ranking- and multiple choice questions. Statistical Tests: The cut-off value for consensus and agreement among the majority was ≥75% and ≥60%, respectively, with a median of ≥4 on the Likert scale. Results: Consensus on specific characteristics mainly concerned the discrimination between WTs and non-WTs, and WTs and nephrogenic rest(s) (NR)/nephroblastomatosis. The presence of bilateral lesions (75.0%) and NR/nephroblastomatosis (65.0%) were MRI characteristics indicated as specific for the diagnosis of a WT, and 91.3% of the participants agreed that MRI is useful to distinguish NR/nephroblastomatosis from WT. Furthermore, all participants agreed that age influenced their prediction in the discrimination of pediatric renal tumors. Data Conclusion: Although the discrimination of pediatric renal tumors based on MRI remains challenging, this study identified some specific characteristics for tumor subtypes, based on the shared opinion of experts. These results may guide future validation studies and innovative efforts. Level of Evidence: 3. Technical Efficacy Stage: 3.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Delphi technique
- pediatric
- renal tumor
- Wilms tumor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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van der Beek, Ju ...
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Watson, Tom A.
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Nievelstein, Rut ...
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Brisse, Hervé J.
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Morosi, Carlo
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Lederman, Henriq ...
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show more...
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Coma, Ana
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Gavra, Maria M.
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Vult von Steyern ...
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Lakatos, Karoly
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Breysem, Luc
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Varga, Edit
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Ducou Le Pointe, ...
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Lequin, Maarten ...
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Schäfer, Jürgen ...
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Mentzel, Hans Jo ...
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Hötker, Andreas ...
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Calareso, Giusep ...
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Swinson, Sophie
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Kyncl, Martin
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Granata, Claudio
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Aertsen, Michael
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Di Paolo, Pier L ...
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de Krijger, Rona ...
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Graf, Norbert
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Olsen, Øystein E ...
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Schenk, Jens Pet ...
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van den Heuvel-E ...
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Littooij, Annemi ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
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Journal of Magne ...
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Lund University