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Genome-wide associa...
Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer
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- Hoffmann, Thomas J. (author)
- University of California, San Francisco
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- Passarelli, Michael N. (author)
- University of California, San Francisco
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- Graff, Rebecca E. (author)
- University of California, San Francisco
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- Emami, Nima C. (author)
- University of California, San Francisco
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- Sakoda, Lori C. (author)
- Kaiser Permanente
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- Jorgenson, Eric (author)
- Kaiser Permanente
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- Habel, Laurel A (author)
- Kaiser Permanente
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- Shan, Jun (author)
- Kaiser Permanente
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- Ranatunga, Dilrini K. (author)
- Kaiser Permanente
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- Quesenberry, Charles P. (author)
- Kaiser Permanente
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- Chao, Chun R. (author)
- Kaiser Permanente
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- Ghai, Nirupa R. (author)
- Kaiser Permanente
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- Aaronson, David (author)
- Kaiser Permanente
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- Presti, Joseph (author)
- Kaiser Permanente
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- Nordström, Tobias (author)
- Karolinska Institutet,Karolinska Institute
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- Wang, Zhaoming (author)
- National Cancer Institute, USA
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- Berndt, Sonja I (author)
- National Cancer Institute, USA
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- Chanock, Stephen J (author)
- National Cancer Institute, USA
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- Mosley, Jonathan D. (author)
- Vanderbilt University
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- Klein, Robert J. (author)
- Icahn School of Medicine at Mount Sinai,University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Middha, Mridu (author)
- Memorial Sloan-Kettering Cancer Center,University of Oxford,Icahn School of Medicine at Mount Sinai
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- Lilja, Hans (author)
- Lund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,University of Oxford,Memorial Sloan-Kettering Cancer Center
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- Melander, Olle (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Kvale, Mark N. (author)
- University of California, San Francisco
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- Kwok, Pui Yan (author)
- University of California, San Francisco
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- Schaefer, Catherine (author)
- Kaiser Permanente
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- Risch, Neil (author)
- University of California, San Francisco,Kaiser Permanente
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- Van Den Eeden, Stephen K (author)
- University of California, San Francisco,Kaiser Permanente
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- Witte, John S. (author)
- University of California, San Francisco
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(creator_code:org_t)
- 2017-01-31
- 2017
- English.
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
- Related links:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa - such as genetics - can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10-8) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels. These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Hoffmann, Thomas ...
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Passarelli, Mich ...
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Graff, Rebecca E ...
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Emami, Nima C.
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Sakoda, Lori C.
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Jorgenson, Eric
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show more...
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Habel, Laurel A
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Shan, Jun
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Ranatunga, Dilri ...
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Quesenberry, Cha ...
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Chao, Chun R.
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Ghai, Nirupa R.
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Aaronson, David
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Presti, Joseph
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Nordström, Tobia ...
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Wang, Zhaoming
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Berndt, Sonja I
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Chanock, Stephen ...
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Mosley, Jonathan ...
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Klein, Robert J.
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Middha, Mridu
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Lilja, Hans
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Melander, Olle
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Kvale, Mark N.
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Kwok, Pui Yan
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Schaefer, Cather ...
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Risch, Neil
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Van Den Eeden, S ...
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Witte, John S.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Lund University
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Karolinska Institutet