SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:lup.lub.lu.se:4026667a-89cb-461a-96ce-78aec2ed24a9"
 

Search: onr:"swepub:oai:lup.lub.lu.se:4026667a-89cb-461a-96ce-78aec2ed24a9" > Genome-wide associa...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Hoffmann, Thomas J.University of California, San Francisco (author)

Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-01-31
  • Springer Science and Business Media LLC,2017

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:4026667a-89cb-461a-96ce-78aec2ed24a9
  • https://lup.lub.lu.se/record/4026667a-89cb-461a-96ce-78aec2ed24a9URI
  • https://doi.org/10.1038/ncomms14248DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135101323URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa - such as genetics - can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P<5 × 10-8) single-nucleotide polymorphisms (SNPs): 19 novel, 15 previously identified for PSA (14 of which were also PCa-associated), and 6 previously identified for PCa only. Further analysis incorporating PCa cases suggests that at least half of the 40 SNPs are PSA-associated independent of PCa. The 40 SNPs explain 9.5% of PSA variation in non-Hispanic whites, and the remaining GWAS SNPs explain an additional 31.7%; this percentage is higher in younger men, supporting the genetic basis of PSA levels. These findings provide important information about genetic markers for PSA that may improve PCa screening, thereby reducing over-diagnosis and over-treatment.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Passarelli, Michael N.University of California, San Francisco (author)
  • Graff, Rebecca E.University of California, San Francisco (author)
  • Emami, Nima C.University of California, San Francisco (author)
  • Sakoda, Lori C.Kaiser Permanente (author)
  • Jorgenson, EricKaiser Permanente (author)
  • Habel, Laurel AKaiser Permanente (author)
  • Shan, JunKaiser Permanente (author)
  • Ranatunga, Dilrini K.Kaiser Permanente (author)
  • Quesenberry, Charles P.Kaiser Permanente (author)
  • Chao, Chun R.Kaiser Permanente (author)
  • Ghai, Nirupa R.Kaiser Permanente (author)
  • Aaronson, DavidKaiser Permanente (author)
  • Presti, JosephKaiser Permanente (author)
  • Nordström, TobiasKarolinska Institutet,Karolinska Institute (author)
  • Wang, ZhaomingNational Cancer Institute, USA (author)
  • Berndt, Sonja INational Cancer Institute, USA (author)
  • Chanock, Stephen JNational Cancer Institute, USA (author)
  • Mosley, Jonathan D.Vanderbilt University (author)
  • Klein, Robert J.Memorial Sloan-Kettering Cancer Center,University of Oxford,Icahn School of Medicine at Mount Sinai (author)
  • Middha, MriduIcahn School of Medicine at Mount Sinai,Memorial Sloan-Kettering Cancer Center,University of Oxford (author)
  • Lilja, HansLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,University of Oxford,Memorial Sloan-Kettering Cancer Center(Swepub:lu)klke-hli (author)
  • Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups(Swepub:lu)endo-ome (author)
  • Kvale, Mark N.University of California, San Francisco (author)
  • Kwok, Pui YanUniversity of California, San Francisco (author)
  • Schaefer, CatherineKaiser Permanente (author)
  • Risch, NeilUniversity of California, San Francisco,Kaiser Permanente (author)
  • Van Den Eeden, Stephen KUniversity of California, San Francisco,Kaiser Permanente (author)
  • Witte, John S.University of California, San Francisco (author)
  • University of California, San FranciscoKaiser Permanente (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Science and Business Media LLC82041-1723

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view