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Icodextrin improves...
Icodextrin improves the fluid status of peritoneal dialysis patients: Results of a double-blind randomized controlled trial
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Davies, SJ (author)
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Woodrow, G (author)
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Donovan, K (author)
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Plum, J (author)
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Williams, P (author)
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Johansson, AC (author)
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Bosselmann, HP (author)
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Heimburger, O (author)
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- Simonsen, Ole (author)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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Davenport, A (author)
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Tranaeus, A (author)
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Divino, JC (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Journal of the American Society of Nephrology. - 1046-6673. ; 14:9, s. 2338-2344
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Abstract
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- Worsening fluid balance results in reduced technique and patient survival in peritoneal dialysis. Under these conditions, the glucose polymer icodextrin is known to enhance ultrafiltration in the long dwell. A multicenter, randomized, double-blind, controlled trial was undertaken to compare icodextrin versus 2.27% glucose to establish whether icodextrin improves fluid status. Fifty patients with urine output <750 ml/d, high solute transport, and either treated hypertension or untreated BP >140/90 mmHg, or a requirement for the equivalent of all 2.27% glucose exchanges, were randomized 1: 1 and evaluated at 1, 3, and 6 mo. Members of the icodextrin group lost weight, whereas the control group gained weight. Similar differences in total body water were observed, largely explained by reduced extracellular fluid volume in those receiving icodextrin, who also achieved better ultrafiltration and total sodium losses at 3 mo (P < 0.05) and had better maintenance of urine volume at 6 mo (P = 0.039). In patients fulfilling the study's inclusion criteria, the use of icodextrin, when compared with 2.27% glucose, in the long exchange improves fluid removal and status in peritoneal dialysis. This effect is apparent within I mo of commencement and was sustained for 6 mo without harmful effects on residual renal function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Davies, SJ
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Woodrow, G
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Donovan, K
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Plum, J
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Williams, P
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Johansson, AC
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show more...
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Bosselmann, HP
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Heimburger, O
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Simonsen, Ole
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Davenport, A
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Tranaeus, A
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Divino, JC
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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Lund University