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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04681naa a2200421 4500 | |
| 001 | oai:lup.lub.lu.se:408e3baa-73f2-4901-a2fd-1e1db19725c9 | |
| 003 | SwePub | |
| 008 | 160401s1996 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/11101482 URI |
| 024 | 7 | a https://doi.org/10.1007/BF028255092 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Axelson, Janu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-ja0 |
| 245 | 1 0 | a The changes in the rat parotid glands following total parenteral nutrition and pancreatico-biliary diversion are not mediated by cholecystokinin |
| 264 | 1 | c 1996 |
| 520 | a CONCLUSIONS: The results of the present study suggest that the pancreas and parotid glands both respond with hypoplasia during absence of food in the digestive tract and with hyperplasia following pancreatico-biliary diversion (PBD). Factors other than cholecystokinin (CCK) are, however, involved in the effects on the parotid glands, since infusion of CCK-8S and devazepide was without influence. BACKGROUND AND AIM: Total parenteral nutrition (TPN) causes reduced pancreatic weight, whereas PBD evokes hyperCCKemia and enlargement of the rat pancreas. The pancreas and parotid glands have in part similar morphology and function. Therefore, we studied the possible presence of alterations also in the parotid glands during TPN, after PBD and during infusion of sulfated cholecystokinin (CCK-8S) and the CCK-A receptor antagonist devazepide, respectively. MATERIALS AND RESULTS: Rats either received TPN for 7 d, or were kept under otherwise identical conditions with free access to food and water. TPN markedly reduced both pancreatic and parotid wet weight and thereby also the protein and amylase contents, and pancreatic DNA content was decreased. There was a significant correlation between the pancreas and parotid glands when comparing these parameters. The concentration of plasma CCK was unaffected by TPN. PBD caused a sevenfold increase in plasma CCK and a three fold increase in the pancreatic weight compared to control rats 28 d after the operation. The protein and DNA contents in the pancreas were found to be increased. The parotid glands increased twofold in weight, but their protein and amylase contents were not affected. There was a significant correlation between the pancreas and parotid glands when comparing weight, and protein and amylase concentrations. Infusion of CCK-8S during 28 d caused a marked increase in pancreatic wet wt and protein and DNA contents. The CCK-A receptor antagonist devazepide induced a reduction in protein and DNA contents in the pancreas. The parotid glands were not affected by either treatment. No effect on the labeling index of serous and ductal cells of the parotid gland was seen at 36 h, 3, 7, and 28 d of infusion with CCK-8S or devazepide. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a devazepide | |
| 653 | a Cholecystokinin (CCK) | |
| 653 | a pancreas | |
| 653 | a pancreatico-biliary diversion (PBD) | |
| 653 | a parotid glands | |
| 653 | a total parenteral nutrition (TPN) | |
| 653 | a trophic effects | |
| 700 | 1 | a Fan, Bo Guang4 aut |
| 700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Enheten för kroniska inflammatoriska och degenerativa sjukdomar,Forskargrupper vid Lunds universitet,Chronic Inflammatory and Degenerative Diseases Research Unit,Lund University Research Groups4 aut0 (Swepub:lu)kir-boh |
| 700 | 1 | a Rehfeld, Jens4 aut |
| 700 | 1 | a Ekelund, Matsu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-mek |
| 700 | 1 | a Ihse, Ingemaru Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-iih |
| 710 | 2 | a Kirurgib Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t International Journal of Pancreatologyg 20:2, s. 109-118q 20:2<109-118x 0169-4197 |
| 856 | 4 | u http://dx.doi.org/10.1007/BF02825509y FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1110148 |
| 856 | 4 8 | u https://doi.org/10.1007/BF02825509 |
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