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Search: onr:"swepub:oai:lup.lub.lu.se:40b917ed-e63f-4dbd-b67a-d3c5506d16e9" > Transferability of ...

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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003330naa a2200553 4500
001oai:lup.lub.lu.se:40b917ed-e63f-4dbd-b67a-d3c5506d16e9
003SwePub
008160401s2006 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/3786652 URI
0247 a https://doi.org/10.1038/ng18992 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a de Bakker, Paul I. W.4 aut
2451 0a Transferability of tag SNPs in genetic association studies in multiple populations
264 c 2006-10-22
264 1b Springer Science and Business Media LLC,c 2006
520 a A general question for linkage disequilibrium-based association studies is how power to detect an association is compromised when tag SNPs are chosen from data in one population sample and then deployed in another sample. Specifically, it is important to know how well tags picked from the HapMap DNA samples capture the variation in other samples. To address this, we collected dense data uniformly across the four HapMap population samples and eleven other population samples. We picked tag SNPs using genotype data we collected in the HapMap samples and then evaluated the effective coverage of these tags in comparison to the entire set of common variants observed in the other samples. We simulated case-control association studies in the non-HapMap samples under a disease model of modest risk, and we observed little loss in power. These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
7001 a Burtt, Noel P.4 aut
7001 a Graham, Robert R.4 aut
7001 a Guiducci, Candace4 aut
7001 a Yelensky, Roman4 aut
7001 a Drake, Jared A.4 aut
7001 a Bersaglieri, Todd4 aut
7001 a Penney, Kathryn L.4 aut
7001 a Butler, Johannah4 aut
7001 a Young, Stanton4 aut
7001 a Onofrio, Robert C.4 aut
7001 a Lyon, Helen N.4 aut
7001 a O Stram, Daniel4 aut
7001 a Haiman, Christopher A.4 aut
7001 a Freedman, Matthew L.4 aut
7001 a Zhu, Xiaofeng4 aut
7001 a Cooper, Richard4 aut
7001 a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr
7001 a Kolonel, Laurence N.4 aut
7001 a Henderson, Brian E.4 aut
7001 a Daly, Mark J.4 aut
7001 a Hirschhorn, Joel N.4 aut
7001 a Altshuler, David4 aut
7102 a Genomik, diabetes och endokrinologib Forskargrupper vid Lunds universitet4 org
7730 t Nature Geneticsd : Springer Science and Business Media LLCg 38:11, s. 1298-1303q 38:11<1298-1303x 1546-1718x 1061-4036
8564 u http://dx.doi.org/10.1038/ng1899y FULLTEXT
8564 8u https://lup.lub.lu.se/record/378665
8564 8u https://doi.org/10.1038/ng1899

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