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Outcome of percutan...
Outcome of percutaneous coronary intervention with the Absorb bioresorbable scaffold : Data from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)
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- Grimfjärd, Per (author)
- Uppsala universitet,Uppsala University,Västmanland Hospital,Kardiologi,Department of Cardiology, Västerås Hospital, Västerås, Sweden
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- James, Stefan, 1964- (author)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Persson, Jonas (author)
- Karolinska Institutet
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- Angerås, Oskar (author)
- Sahlgrenska University Hospital, Department of Cardiology, Gothenburg, Sweden
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- Koul, Sasha (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund University, Skåne University Hospital, Department of Cardiology, Clinical Sciences, Lund, Sweden
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- Omerovic, Elmir (author)
- Sahlgrenska University Hospital, Department of Cardiology, Gothenburg, Sweden
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- Varenhorst, Christoph, 1977- (author)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Lagerqvist, Bo, 1952- (author)
- Uppsala universitet,Uppsala University,Uppsala University Hospital,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Erlinge, David (author)
- Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Lund University, Skåne University Hospital, Department of Cardiology, Clinical Sciences, Lund, Sweden
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(creator_code:org_t)
- 2017
- 2017
- English 8 s.
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In: EuroIntervention. - 1774-024X .- 1969-6213. ; 13:11, s. 1304-1311
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Abstract
Subject headings
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- Aims: Randomised trials indicate higher rates of stent thrombosis (ST) and target lesion failure (TLF) after percutaneous coronary intervention (PCI) with the Absorb bioresorbable scaffold (BRS) compared with modern drug-eluting stents (DES). We aimed to investigate the outcome of all Swedish patients treated with the Absorb BRS. Methods and results: The Absorb BRS (n=810) was compared with commonly used modern DES (n=67,909). The main outcome measure was definite ST; mean follow-up was two years. Despite being implanted in a younger, lower-risk population compared with modern DES, the Absorb BRS was associated with a higher crude incidence of definite ST at stent level: 1.5 vs. 0.6%, hazard ratio (HR) 2.38 (95% confidence interval [CI]: 1.34-4.23), adjusted HR 4.34 (95% CI: 2.37-7.94); p<0.001. The patient level adjusted HR was 4.44 (95% CI: 2.25-8.77). Rates of in-stent restenosis were similar for BRS and DES. Non-compliance with dual antiplatelet therapy (DAPT) guidelines was noted in six out of 12 BRS ST events. Three very late ST events occurred with the Absorb BRS. Conclusions: In this real-world observational study, the Absorb BRS was associated with a significantly higher risk of definite ST compared with modern DES. Non-compliance with DAPT guideline recommendations was common among Absorb definite ST events.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Bioresorbable scaffolds
- Drug-eluting stent
- In-stent restenosis
- Stent thrombosis
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Grimfjärd, Per
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James, Stefan, 1 ...
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Persson, Jonas
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Angerås, Oskar
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Koul, Sasha
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Omerovic, Elmir
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show more...
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Varenhorst, Chri ...
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Lagerqvist, Bo, ...
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Erlinge, David
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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EuroIntervention
- By the university
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Lund University
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Uppsala University
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Karolinska Institutet