onr:"swepub:oai:lup.lub.lu.se:41f57f9b-9f5f-4f1f-8ebb-b7786cf58d9f"
Search: onr:"swepub:oai:lup.lub.lu.se:41f57f9b-9f5f-4f1f-8ebb-b7786cf58d9f" > Primate-specific ev...
- 1 of 1
- Previous record
- Next record
- To hitlist
Primate-specific evolution of noncoding element insertion into PLA2G4C and human preterm birth
- Plunkett, Jevon (author)
- Doniger, Scott (author)
- Morgan, Thomas (author)
- show more...
- Haataja, Ritva (author)
- Hallman, Mikko (author)
- Puttonen, Hilkka (author)
- Menon, Ramkumar (author)
- Kuczynski, Edward (author)
- Norwitz, Errol (author)
- Snegovskikh, Victoria (author)
- Palotie, Aarno (author)
- Peltonen, Leena (author)
- DeFranco, Emily A. (author)
- Chaudhari, Bimal P. (author)
- Oates, John (author)
- Boutaud, Olivier (author)
- McGregor, Tracy L. (author)
- McElroy, Jude J. (author)
- Teramo, Kari (author)
- Borecki, Ingrid (author)
- Fay, Justin C. (author)
- Muglia, Louis J. (author)
- show less...
- (creator_code:org_t)
- 2010-12-24
- 2010
- English.
- In: BMC Medical Genomics. - : Springer Science and Business Media LLC. - 1755-8794. ; 3
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background: The onset of birth in humans, like other apes, differs from non-primate mammals in its endocrine physiology. We hypothesize that higher primate-specific gene evolution may lead to these differences and target genes involved in human preterm birth, an area of global health significance. Methods: We performed a comparative genomics screen of highly conserved noncoding elements and identified PLA2G4C, a phospholipase A isoform involved in prostaglandin biosynthesis as human accelerated. To examine whether this gene demonstrating primate-specific evolution was associated with birth timing, we genotyped and analyzed 8 common single nucleotide polymorphisms (SNPs) in PLA2G4C in US Hispanic (n = 73 preterm, 292 control), US White (n = 147 preterm, 157 control) and US Black (n = 79 preterm, 166 control) mothers. Results: Detailed structural and phylogenic analysis of PLA2G4C suggested a short genomic element within the gene duplicated from a paralogous highly conserved element on chromosome 1 specifically in primates. SNPs rs8110925 and rs2307276 in US Hispanics and rs11564620 in US Whites were significant after correcting for multiple tests (p < 0.006). Additionally, rs11564620 (Thr360Pro) was associated with increased metabolite levels of the prostaglandin thromboxane in healthy individuals (p = 0.02), suggesting this variant may affect PLA2G4C activity. Conclusions: Our findings suggest that variation in PLA2G4C may influence preterm birth risk by increasing levels of prostaglandins, which are known to regulate labor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
- BMC Medical Genomics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Plunkett, Jevon
- Doniger, Scott
- Morgan, Thomas
- Haataja, Ritva
- Hallman, Mikko
- Puttonen, Hilkka
- show more...
- Menon, Ramkumar
- Kuczynski, Edwar ...
- Norwitz, Errol
- Snegovskikh, Vic ...
- Palotie, Aarno
- Peltonen, Leena
- Fellman, Vineta
- DeFranco, Emily ...
- Chaudhari, Bimal ...
- Oates, John
- Boutaud, Olivier
- McGregor, Tracy ...
- McElroy, Jude J.
- Teramo, Kari
- Borecki, Ingrid
- Fay, Justin C.
- Muglia, Louis J.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Medical Genetics
- Articles in the publication
- BMC Medical Geno ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
