The impact of peripheral artery disease on major adverse cardiovascular events following myocardial infarction

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Andersen, PatriciaAalborg University Hospital (author)

The impact of peripheral artery disease on major adverse cardiovascular events following myocardial infarction

Article/chapterEnglish2021

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Elsevier BV,2021

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LIBRIS-ID:oai:lup.lub.lu.se:42b9776e-977d-479e-ac4f-a493c519f30a
https://lup.lub.lu.se/record/42b9776e-977d-479e-ac4f-a493c519f30aURI
https://doi.org/10.1016/j.ijcard.2021.08.053DOI

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Language:English
Summary in:English

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Aims: Peripheral artery disease (PAD) constitute a high-risk with adverse clinical outcomes. We aimed to investigate the cardiovascular outcomes following myocardial infarction (MI). Methods and results: This nationwide, Danish register-based follow-up study includes all patients experiencing an MI between 2000 and 2017. Patients with and without PAD were compared. Multivariable logistic regression was used to derive relative risks of 1-year major adverse cardiovascular events (MACE; all-cause mortality, reinfarction, stroke or heart failure). Individual components, cardiovascular mortality, and bleeding, standardized to age, sex and comorbidity distributions of all patients were assessed. MI patients with PAD (n = 5083, 2.9%) were older and more comorbid compared to patients without PAD (n = 174,673). After standardization, PAD was associated with higher 1-year relative risks of MACE (RR 1.21 [95% CI 1.17;1.25]), all-cause (RR 1.29 [95% CI 1.24;1.35]) and cardiovascular mortality (RR 1.3 [95% CI 1.24;1.36]), reinfarction (RR 1.17 [95% CI 1.11;1.22]), stroke (RR 1.12 [95% CI 0.92;1.32]), heart failure (RR 1.22 [95% CI 1.12;1.32]), and bleeding episodes (RR 1.25 [95% CI 1.04,1.46]). Similar results were seen in 30-day survivors after adjustment for antithrombotic post-discharge medication for MACE (RR 1.25 [95% CI 1.20,1.31]), all-cause mortality (RR 1.47 [95% CI 1.37,1.57], cardiovascular mortality (RR 1.49 [95% CI 1.37,1.61]), reinfarction (RR 1.17 [95% CI 1.08,1.12]) and heart failure (RR 1.22 [95% CI 1.12,1.32]). Conclusion: Comparing to patients without PAD, patients with PAD had increased 1-year relative risk of MACE, all-cause mortality, reinfarction, stroke, heart failure, cardiovascular mortality and bleeding following MI. The low prevalence of PAD is suggestive of considerable under-diagnosing.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Major adverse cardiovascular events
Myocardial infarction
Peripheral artery disease

Added entries (persons, corporate bodies, meetings, titles ...)

Kragholm, KristianAalborg University Hospital (author)
Torp-Pedersen, ChristianAalborg University Hospital,Hillerod Hospital (author)
Jensen, Svend EggertAalborg University,Aalborg University Hospital (author)
Attar, RubinaLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Aalborg University Hospital(Swepub:lu)ru0472at (author)
Aalborg University HospitalHillerod Hospital (creator_code:org_t)

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In:International Journal of Cardiology: Elsevier BV345, s. 131-1370167-5273

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