Contact allergy to the active ingredients of Bioban P 1487

• Bioban P 1487, consisting of the 2 active ingredients 4-(2-nitrobutyl)-morpholine (M) and 4,4'-(2-ethyl-2-nitro-1,3-propanediyl)-bis morpholine (DM), is a preservative recommended for mental working fluids. The aims of this study were to assess the frequency of contact allergy to Bioban P 1487, when added to a standard patch test series, as well as to test the individual active ingredients in patients sensitized to Bioban P 1487. Of the patients consecutively tested, 1.5% reacted positively to Bioban P 1487. Positive test reactions were noted in only 4 of 12 Bioban P 1487-sensitized patients tested with the individual active ingredients. Both active ingredients are contact sensitizers, but in most patients with this contact allergy it remains difficult to identify the sensitizing hapten.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

Keyword

Bioban P 1487

CAS 2224-44-4

CAS 1854-23-5

allergic contact dermatitis

delayed hypersensitivity

4

4'-(2-ethyl-2-nitro-1

3-propanediyl)-bis morpholine

high-performance liquid chromatography

metal working fluids

4-(2-nitrobutyl)-morpholine

preservatives

occupational

engineering industry

Publication and Content Type

art (subject category)

ref (subject category)