Search: onr:"swepub:oai:lup.lub.lu.se:4393ebc1-24c7-4e83-b113-0271bae316b8" >
Eosinophils—from cr...
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Jesenak, MilosUniversity Hospital Martin
(author)
Eosinophils—from cradle to grave
- Article/chapterEnglish2023
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LIBRIS-ID:oai:lup.lub.lu.se:4393ebc1-24c7-4e83-b113-0271bae316b8
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https://lup.lub.lu.se/record/4393ebc1-24c7-4e83-b113-0271bae316b8URI
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https://doi.org/10.1111/all.15884DOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.
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Diamant, ZuzanaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-zdt
(author)
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Simon, DagmarBern University Hospital
(author)
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Tufvesson, EllenLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neonatologi,Forskargrupper vid Lunds universitet,Tornbladinstitutet,Lungfysiologi och biomarkörer,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Neonatology,Lund University Research Groups,Tornblad Institute,Lung physiology and biomarkers(Swepub:lu)medk-etu
(author)
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Seys, Sven F.Catholic University of Leuven
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Mukherjee, ManaliMcMaster University
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Lacy, PaigeUniversity of Alberta
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Vijverberg, SusanneUniversity of Amsterdam
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Slisz, TomasCharles University in Prague
(author)
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Sediva, AnnaUniversity Hospital Motol
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Simon, Hans UweUniversity of Bern
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Striz, IljaInstitute for Clinical and Experimental Medicine (IKEM)
(author)
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Plevkova, JanaComenius University
(author)
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Schwarze, JurgenUniversity of Edinburgh
(author)
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Kosturiak, RadovanComenius University
(author)
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Alexis, Neil E.University of North Carolina
(author)
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Untersmayr, EvaMedical University of Vienna
(author)
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Vasakova, Martina KoziarCharles University in Prague
(author)
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Knol, EdwardUniversity Medical Center Utrecht
(author)
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Koenderman, LeoUniversity Medical Center Utrecht
(author)
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University Hospital MartinInstitutionen för kliniska vetenskaper, Lund
(creator_code:org_t)
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In:Allergy: European Journal of Allergy and Clinical Immunology78:12, s. 3077-31020105-4538
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Jesenak, Milos
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Diamant, Zuzana
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Simon, Dagmar
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Tufvesson, Ellen
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Seys, Sven F.
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Mukherjee, Manal ...
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Lacy, Paige
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Vijverberg, Susa ...
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Slisz, Tomas
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Sediva, Anna
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Simon, Hans Uwe
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Striz, Ilja
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Plevkova, Jana
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Schwarze, Jurgen
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Kosturiak, Radov ...
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Alexis, Neil E.
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Untersmayr, Eva
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Vasakova, Martin ...
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Knol, Edward
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Koenderman, Leo
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