Electrochemical and spectroscopic evidences of the interaction between DNA and Pt(II)(dppf)-complex

Mello, Lucilene D. (author)

Ribeiro, Emerson S. (author)

Kubota, Lauro T. (author)

Elmroth, Sofi (author): Lund University,Lunds universitet,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH

Pereira, Regina M. S. (author)

(creator_code:org_t)

2008-11-04
2009
English.
In: BioMetals. - : Springer Science and Business Media LLC. - 0966-0844 .- 1572-8773. ; 22:2, s. 385-392

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

The interaction of Pt(II)(dppf)-complex, namely [Pt(dppf)(H2O)(2)](2+) with DNA was investigated by DPV and H-1-NMR techniques. The results showed that the interaction process has been characterized by changes in the electrochemical parameters of both compounds and the formation of a new anodic current peak close to the anodic current peak of the [Pt(dppf)(H2O)(2)](2+). In addition, the H-1-NMR spectra show that the coordination of Pt(II)(dppf)-complex to dsDNA occurs via N(7) of guanine. Others parameters like pH and ionic strength that affect the interaction process were also investigated.

By the author/editor: Mello, Lucilene ...; Ribeiro, Emerson ...; Kubota, Lauro T.; Elmroth, Sofi; Pereira, Regina ...

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