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The MAP kinase subs...
The MAP kinase substrate MKS1 is a regulator of plant defence responces
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- Andreasson, Erik (author)
- Lund University,Lunds universitet,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science
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Jenkins, Thomas (author)
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Brodersen, Peter (author)
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Thorgrimsen, Stephan (author)
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Petersen, Nikolaj HT (author)
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Zhu, Shijiang (author)
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Qiu, Jin-Long (author)
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Qiu, Jin-Long (author)
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Micheelsen, Pernille (author)
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Rocher, Anne (author)
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Petersen, Morten (author)
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Newman, Mari-Anne (author)
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Nielsen, Henrik Bjørn (author)
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Hirt, Heribert (author)
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Somssich, Imre (author)
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Mattsson, Ole (author)
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Mundy, John (author)
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(creator_code:org_t)
- 2005-06-30
- 2005
- English.
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In: EMBO Journal. - : Wiley. - 1460-2075 .- 0261-4189. ; 24:14, s. 2579-2589
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Abstract
Subject headings
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- Arabidopsis MAP kinase 4 (MPK4) functions as a regulator of pathogen defense responses, because it is required for both repression of salicylic acid (SA)-dependent resistance and for activation of jasmonate (JA)-dependent defense gene expression. To understand MPK4 signaling mechanisms, we used yeast two-hybrid screening to identify the MPK4 substrate MKS1. Analyses of transgenic plants and genome-wide transcript profiling indicated that MKS1 is required for full SA-dependent resistance in mpk4 mutants, and that overexpression of MKS1 in wild-type plants is sufficient to activate SA-dependent resistance, but does not interfere with induction of a defense gene by JA. Further yeast two-hybrid screening revealed that MKS1 interacts with the WRKY transcription factors WRKY25 and WRKY33. WRKY25 and WRKY33 were shown to be in vitro substrates of MPK4, and a wrky33 knockout mutant was found to exhibit increased expression of the SA-related defense gene PR1. MKS1 may therefore contribute to MPK4-regulated defense activation by coupling the kinase to specific WRKY transcription factors.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- protein kinase
- phosphoserine
- disease resistance
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Andreasson, Erik
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Jenkins, Thomas
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Brodersen, Peter
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Thorgrimsen, Ste ...
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Petersen, Nikola ...
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Zhu, Shijiang
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show more...
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Qiu, Jin-Long
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Micheelsen, Pern ...
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Rocher, Anne
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Petersen, Morten
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Newman, Mari-Ann ...
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Nielsen, Henrik ...
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Hirt, Heribert
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Somssich, Imre
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Mattsson, Ole
-
Mundy, John
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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EMBO Journal
- By the university
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Lund University