onr:"swepub:oai:lup.lub.lu.se:440b7948-37a4-4850-86c8-a3b93d46e793"
Search: onr:"swepub:oai:lup.lub.lu.se:440b7948-37a4-4850-86c8-a3b93d46e793" > Influence of family...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Chattopadhyay, S.Heidelberg University,German Cancer Research Centre (author)
Influence of family history on risk of second primary cancers and survival in patients with squamous cell skin cancer
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-02-06
- Oxford University Press (OUP),2020
- 7 s.
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:440b7948-37a4-4850-86c8-a3b93d46e793
- https://lup.lub.lu.se/record/440b7948-37a4-4850-86c8-a3b93d46e793URI
- https://doi.org/10.1111/bjd.18809DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background: Patients with squamous cell skin cancer (SCC) have an excellent prognosis but second primary cancers (SPCs) weaken survival prospects. Family history is a known risk factor for cancer but whether it is a risk factor for SPC in patients with SCC is not known. Objectives: To quantify the risk of family history on SPCs in patients with SCC and estimate survival probabilities of patients with SPCs depending on family history. Methods: With 13 945 histologically verified SCCs, relative risks (RRs) were estimated for family history using a generalized regression model. For survival analysis, hazard ratios (HRs) were assessed using a multivariable Cox proportional-hazards model. Results: Family history of invasive SCC increased risk of second invasive SCC [RR = 42·92, 95% confidence interval (CI) 33·69–50·32] compared with risk without family history (RR 19·12, 95% CI 17·88–21·08). Family history of any nonskin cancer in invasive SCC increased risk of the same cancers to be diagnosed as SPC (RRFH = 1·48, 95% CI 1·35–1·61 vs. RRno FH = 1·40, 95% CI 1·32–1·48); significant increases were observed for seven different nonskin cancers. Most results were replicated for in situ SCC. SPC was deleterious for survival irrespective of family history; HR for patients with SPC was 4·28 (95% CI 3·83–4·72) vs. those without SPC (1·04). Conclusions: Family history of nonskin cancer was associated with approximately a doubling of risk for SPCs in patients with SCC. SPC increases the death rate in patients with SCC 3–4 times, irrespective of family history. Taking family history into account at SCC diagnosis may help prevention or early detection of SPCs. What's already known about this topic? Second primary cancers (SPCs) are frequently diagnosed in patients with invasive and in situ squamous cell carcinoma (SCC); some epidemiological studies suggest a link to immune dysfunction. Family history of cancer is a risk factor for practically all first primary cancers but whether it also influences risk of SPCs in patients with SCC is not known. The possible influence of family history on survival in patients with SCC remains to be established.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
- Zheng, G.German Cancer Research Centre,Heidelberg University(Swepub:lu)gu4135zh (author)
- Hemminki, A.Helsinki University Central Hospital (author)
- Försti, A.Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Hopp Children’s Cancer Center Heidelberg (KiTZ),German Cancer Research Centre(Swepub:lu)med-asf (author)
- Sundquist, K.Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai(Swepub:lu)med-ksq (author)
- Sundquist, J.Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai(Swepub:lu)med-jsu (author)
- Hemminki, K.Lund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,German Cancer Research Centre,Charles University in Prague(Swepub:lu)med-khk (author)
- Heidelberg UniversityGerman Cancer Research Centre (creator_code:org_t)
Related titles
- In:British Journal of Dermatology: Oxford University Press (OUP)183:3, s. 488-4940007-09631365-2133
Internet link
Find in a library
- British Journal of Dermatology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Chattopadhyay, S ...
- Zheng, G.
- Hemminki, A.
- Försti, A.
- Sundquist, K.
- Sundquist, J.
- show more...
- Hemminki, K.
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- British Journal ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
