Search: onr:"swepub:oai:lup.lub.lu.se:44133c31-2227-4af7-92de-e9f62cf6cd7d" >
Increased DNA methy...
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Paul, Dirk S.University of Cambridge,University College London
(author)
Increased DNA methylation variability in type 1 diabetes across three immune effector cell types
- Article/chapterEnglish2016
Publisher, publication year, extent ...
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2016-11-29
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Springer Science and Business Media LLC,2016
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:44133c31-2227-4af7-92de-e9f62cf6cd7d
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https://lup.lub.lu.se/record/44133c31-2227-4af7-92de-e9f62cf6cd7dURI
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https://doi.org/10.1038/ncomms13555DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide association study across 406,365 CpGs in 52 monozygotic twin pairs discordant for T1D in three immune effector cell types. We observe a substantial enrichment of differentially variable CpG positions (DVPs) in T1D twins when compared with their healthy co-twins and when compared with healthy, unrelated individuals. These T1D-associated DVPs are found to be temporally stable and enriched at gene regulatory elements. Integration with cell type-specific gene regulatory circuits highlight pathways involved in immune cell metabolism and the cell cycle, including mTOR signalling. Evidence from cord blood of newborns who progress to overt T1D suggests that the DVPs likely emerge after birth. Our findings, based on 772 methylomes, implicate epigenetic changes that could contribute to disease pathogenesis in T1D.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Teschendorff, Andrew E.Shanghai Institute for Biological Sciences Chinese Academy of Sciences,University College London
(author)
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Dang, Mary A NQueen Mary University
(author)
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Lowe, RobertQueen Mary University
(author)
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Hawa, Mohammed I.Queen Mary University
(author)
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Ecker, SimoneUniversity College London
(author)
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Beyan, HuriyaQueen Mary University
(author)
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Cunningham, StephanieQueen Mary University
(author)
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Fouts, Alexandra R.University of Colorado
(author)
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Ramelius, AnitaLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ani
(author)
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Burden, FrancesUniversity of Cambridge,National Health Service Blood and Transplant
(author)
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Farrow, SamanthaNational Health Service Blood and Transplant,University of Cambridge
(author)
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Rowlston, SophiaUniversity of Cambridge,National Health Service Blood and Transplant
(author)
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Rehnstrom, KarolaNational Health Service Blood and Transplant
(author)
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Frontini, MattiaNational Health Service Blood and Transplant,University of Cambridge
(author)
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Downes, KateUniversity of Cambridge,National Health Service Blood and Transplant
(author)
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Busche, StephanMcGill University
(author)
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Cheung, Warren A.McGill University
(author)
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Ge, BingMcGill University
(author)
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Simon, Marie MichelleMcGill University
(author)
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Bujold, DavidMcGill University
(author)
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Kwan, TonyMcGill University
(author)
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Bourque, GuillaumeMcGill University
(author)
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Datta, AvikEuropean Bioinformatics Institute
(author)
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Lowy, ErnestoEuropean Bioinformatics Institute
(author)
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Clarke, LauraEuropean Bioinformatics Institute
(author)
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Flicek, PaulEuropean Bioinformatics Institute
(author)
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Libertini, EmanueleUniversity College London
(author)
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Heath, SimonPompeu Fabra University,Barcelona Institute of Science and Technology
(author)
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Gut, MartaBarcelona Institute of Science and Technology,Pompeu Fabra University
(author)
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Gut, Ivo G.Barcelona Institute of Science and Technology,Pompeu Fabra University
(author)
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Ouwehand, Willem H.Wellcome Trust Sanger Institute,University of Cambridge,National Health Service Blood and Transplant
(author)
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Pastinen, TomiMcGill University
(author)
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Soranzo, NicoleWellcome Trust Sanger Institute,University of Cambridge
(author)
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Hofer, Sabine E.Medical University of Innsbruck
(author)
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Karges, BeateGerman Center for Diabetes Research,RWTH Aachen University
(author)
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Meissner, ThomasHeinrich Heine University Düsseldorf,German Center for Diabetes Research
(author)
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Boehm, Bernhard O.Imperial College London,Nanyang Technological University,University of Ulm
(author)
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Cilio, CorradoLund University,Lunds universitet,Diabetes - immunovirologi,Forskargrupper vid Lunds universitet,Diabetes - Immunovirology,Lund University Research Groups(Swepub:lu)endo-cci
(author)
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Larsson, Helena EldingLund University,Lunds universitet,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Paediatric Endocrinology,Lund University Research Groups(Swepub:lu)pedi-hla
(author)
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Lernmark, ÅkeLund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups(Swepub:lu)endo-ale
(author)
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Steck, Andrea K.University of Colorado
(author)
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Rakyan, Vardhman K.Queen Mary University
(author)
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Beck, StephanUniversity College London
(author)
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Leslie, R. DavidQueen Mary University
(author)
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University of CambridgeUniversity College London
(creator_code:org_t)
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In:Nature Communications: Springer Science and Business Media LLC72041-1723
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- By the author/editor
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Paul, Dirk S.
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Teschendorff, An ...
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Dang, Mary A N
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Lowe, Robert
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Hawa, Mohammed I ...
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Ecker, Simone
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show more...
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Beyan, Huriya
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Cunningham, Step ...
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Fouts, Alexandra ...
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Ramelius, Anita
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Burden, Frances
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Farrow, Samantha
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Rowlston, Sophia
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Rehnstrom, Karol ...
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Frontini, Mattia
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Downes, Kate
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Busche, Stephan
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Cheung, Warren A ...
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Ge, Bing
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Simon, Marie Mic ...
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Bujold, David
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Kwan, Tony
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Bourque, Guillau ...
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Datta, Avik
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Lowy, Ernesto
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Clarke, Laura
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Flicek, Paul
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Libertini, Emanu ...
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Heath, Simon
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Gut, Marta
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Gut, Ivo G.
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Ouwehand, Willem ...
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Pastinen, Tomi
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Soranzo, Nicole
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Hofer, Sabine E.
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Karges, Beate
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Meissner, Thomas
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Boehm, Bernhard ...
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Cilio, Corrado
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Larsson, Helena ...
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Lernmark, Åke
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Steck, Andrea K.
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Rakyan, Vardhman ...
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Beck, Stephan
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Leslie, R. David
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