Search: onr:"swepub:oai:lup.lub.lu.se:44d20f73-2549-4f7c-a17a-f1c4cc1c021a" >
Minimal and hybrid ...
Minimal and hybrid hydrogenases are active from archaea
-
- Greening, Chris (author)
- Monash University
-
- Cabotaje, Princess R (author)
- Uppsala University
-
- Valentin Alvarado, Luis E (author)
- University of California, Berkeley
-
show more...
-
- Leung, Pok Man (author)
- Monash University
-
- Land, Henrik (author)
- Uppsala University
-
- Rodrigues-Oliveira, Thiago (author)
- University of Vienna
-
- Ponce-Toledo, Rafael I (author)
- University of Vienna
-
- Senger, Moritz (author)
- Uppsala University
-
- Klamke, Max A (author)
- Uppsala University
-
- Milton, Michael (author)
- Monash University
-
- Lappan, Rachael (author)
- Monash University
-
- Mullen, Susan (author)
- University of California, Berkeley
-
- West-Roberts, Jacob (author)
- University of California, Berkeley
-
- Mao, Jie (author)
- Monash University
-
- Song, Jiangning (author)
- Monash University
-
- Schoelmerich, Marie (author)
- University of California, Berkeley
-
- Stairs, Courtney W (author)
- Lund University,Lunds universitet,Mikrobiologigruppen,Forskargrupper vid Lunds universitet,Molekylär biovetenskap,Avdelningar vid Biologiska institutionen,Biologiska institutionen,Naturvetenskapliga fakulteten,Microbiology Group,Lund University Research Groups,Molecular biosciences,Sections at the Department of Biology,Department of Biology,Faculty of Science
-
- Schleper, Christa (author)
- University of Vienna
-
- Grinter, Rhys (author)
- Monash University
-
- Spang, Anja (author)
- University of Amsterdam
-
- Banfield, Jillian F (author)
- Monash University
-
- Berggren, Gustav (author)
- Uppsala University
-
show less...
-
(creator_code:org_t)
- English.
-
In: Cell. - 1097-4172. ; 187
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Microbial hydrogen (H 2) cycling underpins the diversity and functionality of diverse anoxic ecosystems. Among the three evolutionarily distinct hydrogenase superfamilies responsible, [FeFe] hydrogenases were thought to be restricted to bacteria and eukaryotes. Here, we show that anaerobic archaea encode diverse, active, and ancient lineages of [FeFe] hydrogenases through combining analysis of existing and new genomes with extensive biochemical experiments. [FeFe] hydrogenases are encoded by genomes of nine archaeal phyla and expressed by H 2-producing Asgard archaeon cultures. We report an ultraminimal hydrogenase in DPANN archaea that binds the catalytic H-cluster and produces H 2. Moreover, we identify and characterize remarkable hybrid complexes formed through the fusion of [FeFe] and [NiFe] hydrogenases in ten other archaeal orders. Phylogenetic analysis and structural modeling suggest a deep evolutionary history of hybrid hydrogenases. These findings reveal new metabolic adaptations of archaea, streamlined H 2 catalysts for biotechnological development, and a surprisingly intertwined evolutionary history between the two major H 2-metabolizing enzymes.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
-
Cell
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Greening, Chris
-
Cabotaje, Prince ...
-
Valentin Alvarad ...
-
Leung, Pok Man
-
Land, Henrik
-
Rodrigues-Olivei ...
-
show more...
-
Ponce-Toledo, Ra ...
-
Senger, Moritz
-
Klamke, Max A
-
Milton, Michael
-
Lappan, Rachael
-
Mullen, Susan
-
West-Roberts, Ja ...
-
Mao, Jie
-
Song, Jiangning
-
Schoelmerich, Ma ...
-
Stairs, Courtney ...
-
Schleper, Christ ...
-
Grinter, Rhys
-
Spang, Anja
-
Banfield, Jillia ...
-
Berggren, Gustav
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Microbiology
- Articles in the publication
-
Cell
- By the university
-
Lund University