Oral provocation of patients allergic to sesquiterpene lactones with German chamomile tea to demonstrate possible systemic allergic dermatitis

Lundh, Kerstin (author): Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital,Halmstad County Hospital

Gruvberger, Birgitta (author): Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Skåne University Hospital

Hindsén, Monica (author): Lund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups,Skåne University Hospital

Zimerson, Erik (author): Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital

Svensson, Åke (author): Lund University,Lunds universitet,Dermatologi,Forskargrupper vid Lunds universitet,Dermatology,Lund University Research Groups,Skåne University Hospital

Bruze, Magnus (author): Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital

(creator_code:org_t)

2020-04-16
2020
English 11 s.
In: Contact Dermatitis. - : Wiley. - 0105-1873 .- 1600-0536. ; 83:1, s. 8-18

Related links:: http://dx.doi.org/10...; show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Abstract Subject headings

Background: Most patients with contact allergy to Asteraceae plants are patch test positive to sesquiterpene lactone mix (SLM). There are several reports among these patients of a flare-up of hand eczema after ingestion of food and beverages originating from Asteraceae plants. Aim: To investigate whether German chamomile tea can elicit systemic allergic dermatitis. Patients and Methods: Individuals with or without contact allergy to SLM were patch tested with an extract of German chamomile tea. Six weeks later, they were provoked with capsules containing either freeze-dried German chamomile tea or placebo capsules containing lactose, in a double-blind, randomized study. A numerical rating scale (NRS) was used to ascertain the volunteers' opinion of their hand eczema status. The study individuals were examined to detect a possible flare-up of healed patch test reactions to chamomile. Results: None of the subjects had a flare-up of healed patch test reactions. According to the NRS, SLM-positive individuals experienced a significant worsening of hand eczema, independently of whether they received chamomile or lactose capsules. Conclusion: No evidence suggestive of systemic allergic dermatitis was found.

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)

By the author/editor: Lundh, Kerstin; Gruvberger, Birg ...; Persson, Lena; Hindsén, Monica; Zimerson, Erik; Svensson, Åke; show more...; Bruze, Magnus; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Dermatology and ...

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