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In Vitro Neo-Cartil...
In Vitro Neo-Cartilage Formation on a Three-Dimensional Composite Polymeric Cryogel Matrix
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Bhat, Sumrita (author)
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- Lidgren, Lars (author)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Kumar, Ashok (author)
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(creator_code:org_t)
- 2013-04-25
- 2013
- English.
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In: Macromolecular Bioscience. - : Wiley. - 1616-5195 .- 1616-5187. ; 13:7, s. 827-837
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Limited blood supply and the avascular nature of articular cartilage restricts its self repair capacity, frequently leading to osteoarthritis. This work focuses on scaffolds for tissue repair from natural polymers, for example gelatin, chitosan, and agarose in the form of composite. A novel way of fabrication, known as cryogelation, is presented, in which matrices are synthesized at sub-zero temperature. Cell seeded scaffolds incubated under appropriate conditions result in the accumulation of matrix components on the surface of the gel in the form of neo-cartilage. Neo-cartilage exhibits similarity to native cartilage with respect to its physical, mechanical and biochemical properties. Based on the similarities of neo-cartilage to the native cartilage, it can provide a new approach for the treatment of localised joint injuries.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
Keyword
- chondrocytes
- cryogel scaffolds
- extra-cellular matrix
- neo-cartilage
- osteoarthritis
Publication and Content Type
- art (subject category)
- ref (subject category)
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