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MyelomA Genetics In...
MyelomA Genetics International Consortium
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Morgan, Gareth (author)
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Johnsen, Hans Erik (author)
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Goldschmidt, Hartmut (author)
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Palumbo, Antonio (author)
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Cavo, Michele (author)
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Sonneveld, Pieter (author)
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San Miguel, Jesus (author)
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Chim, Char Sang (author)
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Browne, Paul (author)
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Einsele, Hermann (author)
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Waage, Anders (author)
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Spencer, Andrew (author)
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Hajek, Roman (author)
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Ludwig, Heinz (author)
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Hemminki, Kari (author)
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Houlston, Richard (author)
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(creator_code:org_t)
- 2012-01-03
- 2012
- English.
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In: Leukemia & Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 53:5, s. 796-800
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Abstract
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- While the etiology of multiple myeloma (MM) is largely unknown, evidence for an inherited genetic susceptibility is provided by the two-fold increased risk of the disease seen in first-degree relatives of cases of MM. It is likely that part of this heritable risk is a consequence of the co-inheritance of low-risk genetic variants. The accumulated experience to date in identifying risk variants for other tumors has highlighted difficulties in conducting statistically and methodologically rigorous studies. The MyelomA Genetics International Consortium (MAGIC) includes 16 research groups in Europe, Asia, Australasia, the Middle East and the Americas engaged in studying the genetics of MM. The first goal of MAGIC is to identify and characterize common genetic variants for MM through association-based analyses. Here, we review the rationale for identifying genetic risk variants for MM and our proposed strategy for establishing MAGIC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Multiple myeloma
- genetics
- consortium
- etiology
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- By the author/editor
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Morgan, Gareth
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Johnsen, Hans Er ...
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Goldschmidt, Har ...
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Palumbo, Antonio
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Cavo, Michele
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Sonneveld, Piete ...
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show more...
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San Miguel, Jesu ...
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Chim, Char Sang
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Browne, Paul
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Einsele, Hermann
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Waage, Anders
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Turesson, Ingema ...
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Spencer, Andrew
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Hajek, Roman
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Ludwig, Heinz
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Hemminki, Kari
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Houlston, Richar ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Leukemia & Lymph ...
- By the university
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Lund University