onr:"swepub:oai:lup.lub.lu.se:4654224b-dae2-4fd3-988f-7e05289ccffb"
Search: onr:"swepub:oai:lup.lub.lu.se:4654224b-dae2-4fd3-988f-7e05289ccffb" > Fibroblast Growth F...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Elo, Teresa (author)
Fibroblast Growth Factor 8b Causes Progressive Stromal and Epithelial Changes in the Epididymis and Degeneration of the Seminiferous Epithelium in the Testis of Transgenic Mice
- Article/chapterEnglish2012
Publisher, publication year, extent ...
- Oxford University Press (OUP),2012
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:4654224b-dae2-4fd3-988f-7e05289ccffb
- https://lup.lub.lu.se/record/2991489URI
- https://doi.org/10.1095/biolreprod.111.097352DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Transgenic (Tg) mice expressing human fibroblast growth factor 8b (FGF8-b) under the probasin promoter (Tg [Pbsn-FGF8] L2-L5Elo; hereafter referred to as FGF8-b-Tg) were shown to produce FGF8-b at high levels in the prostate and epididymis and at lower levels in the testis. The present study examined the effects of FGF8-b expression on the epididymis and testis. In old (age, >6 mo) FGF8-b-Tg mice, epididymides were frequently enlarged, with epithelial and stromal hypercellularity progressing upon aging to epithelial dysplasia and malignant transformation of stroma. In addition, oligospermia, dilatation of the duct, and inflammation were frequently observed in the epididymides. In association with the epididymal changes, some FGF8-b-Tg mice presented a degenerative seminiferous epithelium of the testis. Consistent with this observation, infertile males were found in two FGF8-b-Tg mouse lines. Masson trichrome staining and immunohistochemical analysis of smooth muscle actin, laminin, and androgen receptor revealed that changes in the epididymal stroma closely resembled those previously found in the prostates of the FGF8-b-Tg mice. Genes previously found to be upregulated in the prostate of FGF8-b-Tg mice, such as osteopontin (Spp1) connective tissue growth factor (Ctgf), apolipoprotein D (Apod), and FGF receptor 1c (Fgfr1-c), were also upregulated in the epididymides, suggesting that similar molecular mechanisms were active in both tissues. However, unlike in the prostate, the changes in the epididymal epithelium of the FGF8-b-Tg mice did not progress into invasive carcinoma. The results suggest that prolonged and enhanced FGF signaling induces dramatic changes in the epididymis and testis that lead to infertility in a portion of the FGF8-b-Tg males.
Subject headings and genre
- NATURVETENSKAP Biologi hsv//swe
- NATURAL SCIENCES Biological Sciences hsv//eng
- epididymis
- fibroblast growth factor 8
- growth factors
- male
- reproductive tract
- stroma
- testis
- transgenic mouse
- transgenic/knockout model
Added entries (persons, corporate bodies, meetings, titles ...)
- Sipila, Petra (author)
- Valve, Eeva (author)
- Kujala, Paula (author)
- Toppari, Jorma (author)
- Poutanen, Matti (author)
- Härkönen, PirkkoLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)klke-ph0 (author)
- Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)
Related titles
- In:Biology of Reproduction: Oxford University Press (OUP)86:5, s. 157-1571529-72680006-3363
Internet link
Find in a library
- Biology of Reproduction (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Elo, Teresa
- Sipila, Petra
- Valve, Eeva
- Kujala, Paula
- Toppari, Jorma
- Poutanen, Matti
- show more...
- Härkönen, Pirkko
- show less...
- About the subject
-
- NATURAL SCIENCES
- NATURAL SCIENCES
- and Biological Scien ...
- Articles in the publication
- Biology of Repro ...
- By the university
- Lund University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
