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Plasma p-tau217 pre...
Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease
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- Aguillon, David (author)
- University of Antioquia
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- Langella, Stephanie (author)
- Harvard Medical School
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- Chen, Yinghua (author)
- Banner Alzheimer's Institute
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- Sanchez, Justin S. (author)
- Harvard Medical School
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- Su, Yi (author)
- Banner Alzheimer's Institute
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- Vila-Castelar, Clara (author)
- Harvard Medical School
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- Vasquez, Daniel (author)
- University of Antioquia
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska Academy,University College London,Sahlgrenska University Hospital,Hong Kong Center for Neurodegenerative Diseases,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Hansson, Oskar (author)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital
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- Dage, Jeffrey L. (author)
- Indiana University
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- Janelidze, Shorena (author)
- Skåne University Hospital
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- Chen, Kewei (author)
- Banner Alzheimer's Institute
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- Fox-Fuller, Joshua T. (author)
- Harvard Medical School,Boston University
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- Aduen, Paula (author)
- Harvard Medical School
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- Martinez, Jairo E. (author)
- Boston University,Harvard Medical School
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- Garcia, Gloria (author)
- University of Antioquia
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- Baena, Ana (author)
- University of Antioquia
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- Guzman, Claudia (author)
- University of Antioquia
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- Johnson, Keith A. (author)
- Harvard Medical School
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- Sperling, Reisa A. (author)
- Harvard Medical School
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Sahlgrenska University Hospital,Sahlgrenska Academy,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Reiman, Eric M. (author)
- Banner Alzheimer's Institute
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- Lopera, Francisco (author)
- University of Antioquia
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- Quiroz, Yakeel T. (author)
- Harvard Medical School,University of Antioquia
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(creator_code:org_t)
- 2022-12-26
- 2023
- English.
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In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:6, s. 2585-2594
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Abstract
Subject headings
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- Introduction: Plasma-measured tau phosphorylated at threonine 217 (p-tau217) is a potential non-invasive biomarker of Alzheimer's disease (AD). We investigated whether plasma p-tau217 predicts subsequent cognition and positron emission tomography (PET) markers of pathology in autosomal dominant AD. Methods: We analyzed baseline levels of plasma p-tau217 and its associations with amyloid PET, tau PET, and word list delayed recall measured 7.61 years later in non-demented age- and education-matched presenilin-1 E280A carriers (n = 24) and non-carrier (n = 20) family members. Results: Carriers had higher plasma p-tau217 levels than non-carriers. Baseline plasma p-tau217 was associated with subsequent amyloid and tau PET pathology levels and cognitive function. Discussion: Our findings suggest that plasma p-tau217 predicts subsequent brain pathological burden and memory performance in presenilin-1 E280A carriers. These results provide support for plasma p-tau217 as a minimally invasive diagnostic and prognostic biomarker for AD, with potential utility in clinical practice and trials. Highlights: Non-demented presenilin-1 E280A carriers have higher plasma tau phosphorylated at threonine 217 (p-tau217) than do age-matched non-carriers. Higher baseline p-tau217 is associated with greater future amyloid positron emission tomography (PET) pathology burden. Higher baseline p-tau217 is associated with greater future tau PET pathology burden. Higher baseline p-tau217 is associated with worse future memory performance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- autosomal dominant Alzheimer's disease
- blood biomarkers
- dementia
- presenilin-1
- tau pathology
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Aguillon, David
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Langella, Stepha ...
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Chen, Yinghua
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Sanchez, Justin ...
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Su, Yi
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Vila-Castelar, C ...
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show more...
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Vasquez, Daniel
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Zetterberg, Henr ...
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Hansson, Oskar
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Dage, Jeffrey L.
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Janelidze, Shore ...
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Chen, Kewei
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Fox-Fuller, Josh ...
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Aduen, Paula
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Martinez, Jairo ...
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Garcia, Gloria
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Baena, Ana
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Guzman, Claudia
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Johnson, Keith A ...
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Sperling, Reisa ...
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Blennow, Kaj
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Reiman, Eric M.
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Lopera, Francisc ...
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Quiroz, Yakeel T ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer's and ...
- By the university
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Lund University
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University of Gothenburg