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Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use.
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- von Stedingk, Kristoffer (author)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Translational Cancer Research,Department of Laboratory Medicine
- De Preter, Katleen (author)
- Vandesompele, Jo (author)
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- Noguera, Rosa (author)
- Koster, Jan (author)
- Versteeg, Rogier (author)
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- (creator_code:org_t)
- 2015-02-20
- 2015
- English.
- In: International Journal of Cancer. - : Wiley. - 0020-7136. ; 137:4, s. 868-877
- Journal article (peer-reviewed)
Abstract
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- Several gene expression-based prognostic signatures have been described in neuroblastoma, but none have successfully been applied in the clinic. Here we have developed a clinically applicable prognostic gene signature, both with regards to number of genes and analysis platform. Importantly, it does not require comparison between patients and is applicable amongst high-risk patients. The signature is based on a two-gene score (R-score) with prognostic power in high-stage tumours (stage 4 and/or MYCN-amplified diagnosed after 18 months of age). QPCR-based and array-based analyses of matched cDNAs confirmed cross platform (array-qPCR) transferability. We also defined a fixed cut-off value identifying prognostically differing subsets of high-risk patients on an individual patient basis. This gene expression signature independently contributes to the current neuroblastoma classification system, and if prospectively validated could provide further stratification of high-risk patients, and potential upfront identification of a group of patients that are in need of new/additional treatment regimens.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- Versteeg, Rogier
- Påhlman, Sven
- Lindgren, David
- Axelson, Håkan
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