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Association of meta...
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
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Smits, KM (author)
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Benhamou, S (author)
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Garte, S (author)
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show more...
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Weijenberg, MP (author)
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Alamanos, Y (author)
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Ambrosone, C (author)
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Autrup, H (author)
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Autrup, JL (author)
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Baranova, H (author)
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Bathum, L (author)
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Boffetta, P (author)
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Bouchardy, C (author)
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Brockmoller, J (author)
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Butkiewicz, D (author)
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Cascorbi, I (author)
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Clapper, ML (author)
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Coutelle, C (author)
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Daly, AK (author)
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Muzi, G (author)
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Dolzan, V (author)
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Duzhak, TG (author)
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Farker, K (author)
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Golka, K (author)
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Haugen, A (author)
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Hein, DW (author)
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Hildesheim, A (author)
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Hirvonen, A (author)
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Hsieh, LL (author)
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- Ingelman-Sundberg, M (author)
- Karolinska Institutet
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Kalina, I (author)
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Kang, D (author)
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Katoh, T (author)
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Kihara, M (author)
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Ono-Kihara, M (author)
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Kim, H (author)
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Kiyohara, C (author)
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Kremers, P (author)
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Lazarus, P (author)
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Le Marchand, L (author)
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Lechner, MC (author)
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London, S (author)
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Manni, JJ (author)
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Maugard, CM (author)
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Morgan, GJ (author)
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Morita, S (author)
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Nazar-Stewart, V (author)
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Kristensen, VN (author)
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Oda, Y (author)
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Parl, FF (author)
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Peters, WHM (author)
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- Rannug, A (author)
- Karolinska Institutet
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Rebbeck, T (author)
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Pinto, LFR (author)
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Risch, A (author)
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Romkes, M (author)
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Salagovic, J (author)
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Schoket, B (author)
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- Seidegård, Janeric (author)
- Lund University,Lunds universitet,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine
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Shields, PG (author)
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Sim, E (author)
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Sinnett, D (author)
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Strange, RC (author)
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Stucker, I (author)
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Sugimura, H (author)
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To-Figueras, J (author)
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Vineis, P (author)
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Yu, MC (author)
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Zheng, W (author)
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Pedotti, P (author)
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Taioli, E (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: International Journal of Cancer. - : Wiley. - 0020-7136 .- 1097-0215. ; 110:2, s. 266-270
- Related links:
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http://dx.doi.org/10...
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https://onlinelibrar...
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Abstract
Subject headings
Close
- Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20,938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYPIAI, GSTMI, GSTTI, NAT2 and GSTPI. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- pooled analysis
- molecular epidemiology
- smoking
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Smits, KM
-
Benhamou, S
-
Garte, S
-
Weijenberg, MP
-
Alamanos, Y
-
Ambrosone, C
-
show more...
-
Autrup, H
-
Autrup, JL
-
Baranova, H
-
Bathum, L
-
Boffetta, P
-
Bouchardy, C
-
Brockmoller, J
-
Butkiewicz, D
-
Cascorbi, I
-
Clapper, ML
-
Coutelle, C
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Daly, AK
-
Muzi, G
-
Dolzan, V
-
Duzhak, TG
-
Farker, K
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Golka, K
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Haugen, A
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Hein, DW
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Hildesheim, A
-
Hirvonen, A
-
Hsieh, LL
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Ingelman-Sundber ...
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Kalina, I
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Kang, D
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Katoh, T
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Kihara, M
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Ono-Kihara, M
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Kim, H
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Kiyohara, C
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Kremers, P
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Lazarus, P
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Le Marchand, L
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Lechner, MC
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London, S
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Manni, JJ
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Maugard, CM
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Morgan, GJ
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Morita, S
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Nazar-Stewart, V
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Kristensen, VN
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Oda, Y
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Parl, FF
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Peters, WHM
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Rannug, A
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Rebbeck, T
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Pinto, LFR
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Risch, A
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Romkes, M
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Salagovic, J
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Schoket, B
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Seidegård, Janer ...
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Shields, PG
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Sim, E
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Sinnett, D
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Strange, RC
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Stucker, I
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Sugimura, H
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To-Figueras, J
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Vineis, P
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Yu, MC
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Zheng, W
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Pedotti, P
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Taioli, E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Lund University
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Karolinska Institutet