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A genome-wide assoc...
A genome-wide association study in multiple system atrophy
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- Sailer, Anna (author)
- Goethe University
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- Scholz, Sonja W. (author)
- Johns Hopkins Hospital
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- Nalls, Michael A. (author)
- National Institute on Aging, United States
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- Schulte, Claudia (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Federoff, Monica (author)
- National Institute on Aging, United States
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- Price, T. Ryan (author)
- National Institute on Aging, United States
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- Lees, Andrew (author)
- University College London
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- Ross, Owen A. (author)
- Mayo Clinic Florida
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- Dickson, Dennis W. (author)
- Mayo Clinic Florida
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- Mok, Kin (author)
- Hong Kong University of Science and Technology
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- Mencacci, Niccolo E. (author)
- University College London
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- Schottlaender, Lucia (author)
- University College London
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- Chelban, Viorica (author)
- University College London
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- Ling, Helen (author)
- University College London
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- O'Sullivan, Sean S. (author)
- University College London
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- Wood, Nicholas W. (author)
- University College London
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- Traynor, Bryan J. (author)
- National Institute on Aging, United States
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- Ferrucci, Luigi (author)
- National Institute on Aging, United States
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- Federoff, Howard J. (author)
- Georgetown University
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- Mhyre, Timothy R. (author)
- Georgetown University
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- Morris, Huw R. (author)
- University College London
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- Deuschl, Günther (author)
- University of Kiel
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- Quinn, Niall (author)
- University College London
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- Widner, Håkan (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Albanese, Alberto (author)
- Catholic University of the Sacred Heart, Rome
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- Infante, Jon (author)
- University of Cantabria
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- Bhatia, Kailash P. (author)
- University College London
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- Poewe, Werner (author)
- Medical University of Innsbruck
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- Oertel, Wolfgang (author)
- Philipp University of Marburg
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- Höglinger, Günter U. (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Wüllner, Ullrich (author)
- University Hospital Bonn
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- Goldwurm, Stefano (author)
- Istituti Clinici Di Perfezionamento Hospital , Milan
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- Pellecchia, Maria Teresa (author)
- University of Salerno
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- Ferreira, Joaquim (author)
- University of Lisbon
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- Tolosa, Eduardo (author)
- University of Barcelona
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- Bloem, Bastiaan R. (author)
- Radboud University Nijmegen
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- Rascol, Olivier (author)
- Radboud University Medical Center
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- Meissner, Wassilios G. (author)
- University of Bordeaux
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- Hardy, John A. (author)
- University College London
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- Revesz, Tamas (author)
- University College London
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- Holton, Janice L. (author)
- University College London
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- Gasser, Thomas (author)
- German Center for Neurodegenerative Diseases (DZNE), Bonn
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- Wenning, Gregor K. (author)
- Medical University of Innsbruck
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- Singleton, Andrew B. (author)
- National Institute on Aging, United States
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- Houlden, Henry (author)
- University College London
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(creator_code:org_t)
- 2016
- 2016
- English 8 s.
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In: Neurology. - 0028-3878. ; 87:15, s. 1591-1598
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
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- Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. Results: We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10-6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA. Conclusions: We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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- art (subject category)
- ref (subject category)
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Neurology
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- By the author/editor
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Sailer, Anna
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Scholz, Sonja W.
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Nalls, Michael A ...
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Schulte, Claudia
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Federoff, Monica
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Price, T. Ryan
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show more...
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Lees, Andrew
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Ross, Owen A.
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Dickson, Dennis ...
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Mok, Kin
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Mencacci, Niccol ...
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Schottlaender, L ...
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Chelban, Viorica
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Ling, Helen
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O'Sullivan, Sean ...
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Wood, Nicholas W ...
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Traynor, Bryan J ...
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Ferrucci, Luigi
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Federoff, Howard ...
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Mhyre, Timothy R ...
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Morris, Huw R.
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Deuschl, Günther
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Quinn, Niall
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Widner, Håkan
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Albanese, Albert ...
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Infante, Jon
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Bhatia, Kailash ...
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Poewe, Werner
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Oertel, Wolfgang
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Höglinger, Günte ...
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Wüllner, Ullrich
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Goldwurm, Stefan ...
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Pellecchia, Mari ...
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Ferreira, Joaqui ...
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Tolosa, Eduardo
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Bloem, Bastiaan ...
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Rascol, Olivier
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Meissner, Wassil ...
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Hardy, John A.
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Revesz, Tamas
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Holton, Janice L ...
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Gasser, Thomas
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Wenning, Gregor ...
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Singleton, Andre ...
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Houlden, Henry
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Neurology
- By the university
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Lund University