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Mitochondrial Effects of Common Cardiovascular Medications : The Good, the Bad and the Mixed
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- Bețiu, Alina M. (author)
- Victor Babes University of Medicine and Pharmacy
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- Noveanu, Lavinia (author)
- Victor Babes University of Medicine and Pharmacy
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- Hâncu, Iasmina M. (author)
- Victor Babes University of Medicine and Pharmacy
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- (creator_code:org_t)
- 2022-11-07
- 2022
- English.
- In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:21
- Research review (peer-reviewed)
Abstract
Subject headings
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- Mitochondria are central organelles in the homeostasis of the cardiovascular system via the integration of several physiological processes, such as ATP generation via oxidative phosphorylation, synthesis/exchange of metabolites, calcium sequestration, reactive oxygen species (ROS) production/buffering and control of cellular survival/death. Mitochondrial impairment has been widely recognized as a central pathomechanism of almost all cardiovascular diseases, rendering these organelles important therapeutic targets. Mitochondrial dysfunction has been reported to occur in the setting of drug-induced toxicity in several tissues and organs, including the heart. Members of the drug classes currently used in the therapeutics of cardiovascular pathologies have been reported to both support and undermine mitochondrial function. For the latter case, mitochondrial toxicity is the consequence of drug interference (direct or off-target effects) with mitochondrial respiration/energy conversion, DNA replication, ROS production and detoxification, cell death signaling and mitochondrial dynamics. The present narrative review aims to summarize the beneficial and deleterious mitochondrial effects of common cardiovascular medications as described in various experimental models and identify those for which evidence for both types of effects is available in the literature.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- adverse effects
- cardiovascular drugs
- drug interaction
- drug intoxication
- drug toxicity
- lactic acidosis
- mitochondria function and morphology
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- for (subject category)
- ref (subject category)
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- Petrescu, Lucian
- Maack, Christoph
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- Lund University
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