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Predictive Value of...
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Wänman, JohanUmeå universitet,Umeå University,Ortopedi
(author)
Predictive Value of the Spinal Instability Neoplastic Score for Survival and Ambulatory Function After Surgery for Metastatic Spinal Cord Compression in 110 Patients with Prostate Cancer
- Article/chapterEnglish2021
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LIBRIS-ID:oai:lup.lub.lu.se:482c7daa-2559-4897-aa4f-9dec0343e256
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https://lup.lub.lu.se/record/482c7daa-2559-4897-aa4f-9dec0343e256URI
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https://doi.org/10.1097/BRS.0000000000003835DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-182095URI
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Language:English
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Summary in:English
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STUDY DESIGN: We retrospectively analyzed Spinal Instability Neoplastic Score (SINS) in 110 patients with prostate cancer operated for metastatic spinal cord compression (MSCC). OBJECTIVE: We aimed to investigate the association between SINS and clinical outcomes after surgery for MSCC in patients with prostate cancer. SUMMARY OF BACKGROUND DATA: The SINS is a useful tool for assessing tumor-related spinal instability, but its prognostic value regarding survival and neurological outcome is still controversial. METHODS: We analyzed 110 consecutive patients with prostate cancer who underwent surgery for MSCC. The patients were categorized according to their SINS. Patients with castration-resistant prostate cancer (CRPC, n = 84) and those with hormone-naïve disease (n = 26) were analyzed separately. RESULTS: In total, 106 of 110 patients met the SINS criteria for potential instability or instability (scores 7-18). The median SINS was 10 (range 6-15) for patients with CRPC and 9 (7-16) for hormone-naïve patients. In the CRPC group, the SINS was classified as stable (score 0-6) in 4 patients, as potentially unstable (score 7-12) in 70 patients, and as unstable (score 13-18) in 10 patients. In the hormone-naïve group, 22 patients met the SINS criteria for potential instability and 4 patients for instability. There was no statistically significant difference in the overall risk for death between the SINS potentially unstable and unstable categories (adjusted hazard ratio 1.3, P = 0.4), or in the risk of loss of ambulation 1 month after surgery (adjusted odds ratio 1.4, P = 0.6). CONCLUSION: The SINS is helpful in assessing spinal instability when selecting patients for surgery, but it does not predict survival or neurological outcomes. Patients with a potential spinal instability benefit equally from surgery for MSCC as do patients with spinal instability.Level of Evidence: 3.
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Jernberg, JohannesUmeå universitet,Umeå University,Ortopedi
(author)
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Gustafsson, PatrikUmeå universitet,Umeå University,Ortopedi(Swepub:umu)pakgon02
(author)
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Abul-Kasim, KasimLund University,Lunds universitet,Diagnostisk radiologi, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Radiology Diagnostics, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Division of Neuroradiology, Diagnostic Centre for Imaging and Functional Medicine, Lund University, Skåne University Hospital, Lund, Sweden(Swepub:lu)ront-kab
(author)
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Grabowski, PawelUmeå University
(author)
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Bobinski, LukasUmeå universitet,Umeå University,Ortopedi(Swepub:umu)lubo0003
(author)
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Crnalic, SeadUmeå universitet,Umeå University,Ortopedi(Swepub:umu)secr0001
(author)
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Grabowski, RadoslawUmeå universitet,Ortopedi(Swepub:umu)palgri99
(author)
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Umeå UniversityOrtopedi
(creator_code:org_t)
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In:Spine: Wolters Kluwer46:8, s. 550-5580362-24361528-1159
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