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Epigenetic–smoking ...
Epigenetic–smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients
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- Ji, Xinyu (author)
- Nanjing Medical University
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- Lin, Lijuan (author)
- Harvard University,Nanjing Medical University
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- Shen, Sipeng (author)
- Harvard University,Nanjing Medical University
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- Dong, Xuesi (author)
- Harvard University,Southeast University, Nanjing,Nanjing Medical University
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- Chen, Chao (author)
- Nanjing Medical University
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- Li, Yi (author)
- University of Michigan
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- Zhu, Ying (author)
- Nanjing Medical University
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- Huang, Hui (author)
- Nanjing Medical University
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- Chen, Jiajin (author)
- Nanjing Medical University
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- Chen, Xin (author)
- Nanjing Medical University
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- Wei, Liangmin (author)
- Nanjing Medical University
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- He, Jieyu (author)
- Nanjing Medical University
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- Duan, Weiwei (author)
- Nanjing Medical University
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- Su, Li (author)
- Harvard University
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- Jiang, Yue (author)
- Nanjing Medical University
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- Fan, Juanjuan (author)
- Nanjing Medical University
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- Guan, Jinxing (author)
- Nanjing Medical University
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- You, Dongfang (author)
- Nanjing Medical University,Harvard University
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- Shafer, Andrea (author)
- Massachusetts General Hospital
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- Bjaanæs, Maria Moksnes (author)
- Oslo university hospital
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- Karlsson, Anna (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Planck, Maria (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Helland, Åslaug (author)
- Oslo university hospital,University of Oslo
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- Esteller, Manel (author)
- Josep Carreras Leukaemia Research Institute (IJC),Catalan Institution for Research and Advanced Studies,University of Barcelona,Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
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- Wei, Yongyue (author)
- Harvard University,Nanjing Medical University
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- Zhang, Ruyang (author)
- Nanjing Medical University,Harvard University
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- Chen, Feng (author)
- Nanjing Medical University
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- Christiani, David C. (author)
- Harvard University,Massachusetts General Hospital
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(creator_code:org_t)
- 2020-09-03
- 2020
- English 16 s.
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In: Molecular Oncology. - : Wiley. - 1574-7891 .- 1878-0261. ; 14:11, s. 2759-2774
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Abstract
Subject headings
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- Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylation of TRIM27 and overall survival. Significant CpG probes were confirmed in 617 samples from The Cancer Genome Atlas. The methylation of the CpG probe cg05293407TRIM27 was significantly associated with overall survival in patients with LUSC (HR = 1.65, 95% CI: 1.30–2.09, P = 4.52 × 10−5), but not in patients with LUAD (HR = 1.08, 95% CI: 0.87–1.33, P = 0.493). As incidence of LUSC is associated with higher smoking intensity compared to LUAD, we investigated whether smoking intensity impacted on the prognostic effect of cg05293407TRIM27 methylation in NSCLC. LUSC patients had a higher average pack-year of smoking (37.49LUAD vs 54.79LUSC, P = 1.03 × 10−19) and included a higher proportion of current smokers than LUAD patients (28.24%LUAD vs 34.09%LUSC, P = 0.037). cg05293407TRIM27 was significantly associated with overall survival only in NSCLC patients with medium–high pack-year of smoking (HR = 1.58, 95% CI: 1.26–1.96, P = 5.25 × 10−5). We conclude that cg05293407TRIM27 methylation is a potential predictor of LUSC prognosis, and smoking intensity may impact on its prognostic value across the various types of NSCLC.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- DNA methylation
- interaction
- non-small-cell lung cancer
- overall survival
- prognosis
- TRIM27
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Ji, Xinyu
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Lin, Lijuan
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Shen, Sipeng
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Dong, Xuesi
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Chen, Chao
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Li, Yi
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show more...
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Zhu, Ying
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Huang, Hui
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Chen, Jiajin
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Chen, Xin
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Wei, Liangmin
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He, Jieyu
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Duan, Weiwei
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Su, Li
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Jiang, Yue
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Fan, Juanjuan
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Guan, Jinxing
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You, Dongfang
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Shafer, Andrea
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Wei, Yongyue
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Zhang, Ruyang
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Chen, Feng
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Christiani, Davi ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Molecular Oncolo ...
- By the university
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Lund University