Search: onr:"swepub:oai:lup.lub.lu.se:49916c5f-7063-4ca0-9416-a9efb51a181b" >
Anti-tumor effects ...
Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma
-
- Mohlin, Sofie (author)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
-
- Hansson, Karin (author)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
-
- Radke, Katarzyna (author)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
-
show more...
-
- Martinez, Sonia (author)
- Spanish National Cancer Research Center (CNIO)
-
- Blanco-Apiricio, Carmen (author)
- Spanish National Cancer Research Center (CNIO)
-
- Garcia-Ruiz, Cristian (author)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
-
- Welinder, Charlotte (author)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Esfandyari, Javanshir (author)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
-
- O'Neill, Michael (author)
- Inflection Biosciences Ltd
-
- Pastor, Joaquin (author)
- Spanish National Cancer Research Center (CNIO)
-
- von Stedingk, Kristoffer (author)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC)
-
- Bexell, Daniel (author)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
-
show less...
-
(creator_code:org_t)
- 2019-07-16
- 2019
- English.
-
In: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 11:8
- Related links:
-
http://dx.doi.org/10... (free)
-
show more...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The PI3K pathway is a major driver of cancer progression. However, clinical resistance to PI3K inhibition is common. IBL-302 is a novel highly specific triple PIM, PI3K, and mTOR inhibitor. Screening IBL-302 in over 700 cell lines representing 47 tumor types identified neuroblastoma as a strong candidate for PIM/PI3K/mTOR inhibition. IBL-302 was more effective than single PI3K inhibition in vitro, and IBL-302 treatment of neuroblastoma patient-derived xenograft (PDX) cells induced apoptosis, differentiated tumor cells, and decreased N-Myc protein levels. IBL-302 further enhanced the effect of the common cytotoxic chemotherapies cisplatin, doxorubicin, and etoposide. Global genome, proteome, and phospho-proteome analyses identified crucial biological processes, including cell motility and apoptosis, targeted by IBL-302 treatment. While IBL-302 treatment alone reduced tumor growth in vivo, combination therapy with low-dose cisplatin inhibited neuroblastoma PDX growth. Complementing conventional chemotherapy treatment with PIM/PI3K/mTOR inhibition has the potential to improve clinical outcomes and reduce severe late effects in children with high-risk neuroblastoma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cisplatin
- IBL-302
- multikinase inhibition
- neuroblastoma
- PI3K
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mohlin, Sofie
-
Hansson, Karin
-
Radke, Katarzyna
-
Martinez, Sonia
-
Blanco-Apiricio, ...
-
Garcia-Ruiz, Cri ...
-
show more...
-
Welinder, Charlo ...
-
Esfandyari, Java ...
-
O'Neill, Michael
-
Pastor, Joaquin
-
von Stedingk, Kr ...
-
Bexell, Daniel
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
EMBO Molecular M ...
- By the university
-
Lund University